Melissa A Merritt, Sarah Krull Abe, Md Rashedul Islam, Md Shafiur Rahman, Eiko Saito, Ryoko Katagiri, Aesun Shin, Ji-Yeob Choi, Loïc Le Marchand, Jeffrey L Killeen, Yu-Tang Gao, Akiko Tamakoshi, Woon-Puay Koh, Ritsu Sakata, Norie Sawada, Ichiro Tsuji, Yumi Sugawara, Jeongseon Kim, Sue K Park, Sun-Seog Kweon, Xiao-Ou Shu, Takashi Kimura, Jian-Min Yuan, Shoichiro Tsugane, Seiki Kanemura, Yukai Lu, Min-Ho Shin, Wanqing Wen, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang
{"title":"生殖因素和上皮性卵巢癌的风险：来自亚洲队列协会的结果。","authors":"Melissa A Merritt, Sarah Krull Abe, Md Rashedul Islam, Md Shafiur Rahman, Eiko Saito, Ryoko Katagiri, Aesun Shin, Ji-Yeob Choi, Loïc Le Marchand, Jeffrey L Killeen, Yu-Tang Gao, Akiko Tamakoshi, Woon-Puay Koh, Ritsu Sakata, Norie Sawada, Ichiro Tsuji, Yumi Sugawara, Jeongseon Kim, Sue K Park, Sun-Seog Kweon, Xiao-Ou Shu, Takashi Kimura, Jian-Min Yuan, Shoichiro Tsugane, Seiki Kanemura, Yukai Lu, Min-Ho Shin, Wanqing Wen, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang","doi":"10.1038/s41416-024-02924-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There are scarce data on risk factors for epithelial ovarian cancer (EOC) in Asian populations. Our goal was to advance knowledge on reproductive -related risk factors for EOC in a large population of Asian women.</p><p><strong>Methods: </strong>This study used pooled individual data from baseline questionnaires in 11 prospective cohorts (baseline years, 1958-2015) in the Asia Cohort Consortium. A Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusting for age, parity and cohort.</p><p><strong>Results: </strong>After a mean = 17.0 years (SD = 6.3) of follow-up, 674 incident invasive EOC cases were identified among 325,626 women. In multivariable adjusted models we observed an inverse association with parity (5+ children vs. 0, HR = 0.44, 95% CI = 0.28-0.68, Ptrend < 0.001), and a positive association with increasing menopausal age (55+ years vs. <45, HR = 1.77, 95% CI = 1.05-3.01, Ptrend = 0.02) for risk of all EOC.</p><p><strong>Conclusions: </strong>In this large study of Asian women we identified an inverse association with parity and a positive association with higher menopausal age in relation to EOC risk. Further work is needed to understand EOC risk factors for rare histologic subtypes that occur more frequently in Asian populations.</p>","PeriodicalId":9243,"journal":{"name":"British Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":6.4000,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Reproductive factors and risk of epithelial ovarian cancer: results from the Asia Cohort Consortium.\",\"authors\":\"Melissa A Merritt, Sarah Krull Abe, Md Rashedul Islam, Md Shafiur Rahman, Eiko Saito, Ryoko Katagiri, Aesun Shin, Ji-Yeob Choi, Loïc Le Marchand, Jeffrey L Killeen, Yu-Tang Gao, Akiko Tamakoshi, Woon-Puay Koh, Ritsu Sakata, Norie Sawada, Ichiro Tsuji, Yumi Sugawara, Jeongseon Kim, Sue K Park, Sun-Seog Kweon, Xiao-Ou Shu, Takashi Kimura, Jian-Min Yuan, Shoichiro Tsugane, Seiki Kanemura, Yukai Lu, Min-Ho Shin, Wanqing Wen, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang\",\"doi\":\"10.1038/s41416-024-02924-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>There are scarce data on risk factors for epithelial ovarian cancer (EOC) in Asian populations. Our goal was to advance knowledge on reproductive -related risk factors for EOC in a large population of Asian women.</p><p><strong>Methods: </strong>This study used pooled individual data from baseline questionnaires in 11 prospective cohorts (baseline years, 1958-2015) in the Asia Cohort Consortium. A Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusting for age, parity and cohort.</p><p><strong>Results: </strong>After a mean = 17.0 years (SD = 6.3) of follow-up, 674 incident invasive EOC cases were identified among 325,626 women. In multivariable adjusted models we observed an inverse association with parity (5+ children vs. 0, HR = 0.44, 95% CI = 0.28-0.68, Ptrend < 0.001), and a positive association with increasing menopausal age (55+ years vs. <45, HR = 1.77, 95% CI = 1.05-3.01, Ptrend = 0.02) for risk of all EOC.</p><p><strong>Conclusions: </strong>In this large study of Asian women we identified an inverse association with parity and a positive association with higher menopausal age in relation to EOC risk. Further work is needed to understand EOC risk factors for rare histologic subtypes that occur more frequently in Asian populations.</p>\",\"PeriodicalId\":9243,\"journal\":{\"name\":\"British Journal of Cancer\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":6.4000,\"publicationDate\":\"2024-12-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"British Journal of Cancer\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41416-024-02924-z\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"British Journal of Cancer","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41416-024-02924-z","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
Reproductive factors and risk of epithelial ovarian cancer: results from the Asia Cohort Consortium.
Background: There are scarce data on risk factors for epithelial ovarian cancer (EOC) in Asian populations. Our goal was to advance knowledge on reproductive -related risk factors for EOC in a large population of Asian women.
Methods: This study used pooled individual data from baseline questionnaires in 11 prospective cohorts (baseline years, 1958-2015) in the Asia Cohort Consortium. A Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusting for age, parity and cohort.
Results: After a mean = 17.0 years (SD = 6.3) of follow-up, 674 incident invasive EOC cases were identified among 325,626 women. In multivariable adjusted models we observed an inverse association with parity (5+ children vs. 0, HR = 0.44, 95% CI = 0.28-0.68, Ptrend < 0.001), and a positive association with increasing menopausal age (55+ years vs. <45, HR = 1.77, 95% CI = 1.05-3.01, Ptrend = 0.02) for risk of all EOC.
Conclusions: In this large study of Asian women we identified an inverse association with parity and a positive association with higher menopausal age in relation to EOC risk. Further work is needed to understand EOC risk factors for rare histologic subtypes that occur more frequently in Asian populations.
期刊介绍：
The British Journal of Cancer is one of the most-cited general cancer journals, publishing significant advances in translational and clinical cancer research.It also publishes high-quality reviews and thought-provoking comment on all aspects of cancer prevention,diagnosis and treatment.
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