Rho GTPases的结构动力学。

IF 4.7 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Molecular Biology Pub Date : 2025-02-01 DOI:10.1016/j.jmb.2024.168919

Yuan Lin , Yi Zheng

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引用次数: 0

摘要

Rho家族gtpase是Ras超家族的一部分，是许多细胞过程的信号中枢。虽然对Ras结构和功能的详细了解使Ras靶向药物的发现取得了巨大进展，但对相关Rho GTPase的研究也在追赶，因为复发性癌症相关的Rho GTPase突变在过去十年中才被发现。与Ras一样，深入了解Rho GTPases及其突变体如何作为关键的致癌驱动因素的结构基础，有助于开发临床有效的治疗方法。近年来对Rho GTPase结构-功能关系的结构动力学研究为Rho GTPase信号传导机制的传统认识增添了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Structural Dynamics of Rho GTPases

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Structural Dynamics of Rho GTPases

Rho family GTPases are a part of the Ras superfamily and are signaling hubs for many cellular processes. While the detailed understanding of Ras structure and function has led to tremendous progress in oncogenic Ras-targeted drug discovery, studies of the related Rho GTPases are still catching up as the recurrent cancer-related Rho GTPase mutations have only been discovered in the last decade. Like that of Ras, an in-depth understanding of the structural basis of how Rho GTPases and their mutants behave as key oncogenic drivers benefits the development of clinically effective therapies. Recent studies of structure dynamics in Rho GTPase structure–function relationship have added new twists to the conventional wisdom of Rho GTPase signaling mechanism.

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来源期刊

Journal of Molecular Biology 生物-生化与分子生物学

CiteScore

11.30

自引率

1.80%

发文量

412

审稿时长

28 days

期刊介绍： Journal of Molecular Biology (JMB) provides high quality, comprehensive and broad coverage in all areas of molecular biology. The journal publishes original scientific research papers that provide mechanistic and functional insights and report a significant advance to the field. The journal encourages the submission of multidisciplinary studies that use complementary experimental and computational approaches to address challenging biological questions. Research areas include but are not limited to: Biomolecular interactions, signaling networks, systems biology; Cell cycle, cell growth, cell differentiation; Cell death, autophagy; Cell signaling and regulation; Chemical biology; Computational biology, in combination with experimental studies; DNA replication, repair, and recombination; Development, regenerative biology, mechanistic and functional studies of stem cells; Epigenetics, chromatin structure and function; Gene expression; Membrane processes, cell surface proteins and cell-cell interactions; Methodological advances, both experimental and theoretical, including databases; Microbiology, virology, and interactions with the host or environment; Microbiota mechanistic and functional studies; Nuclear organization; Post-translational modifications, proteomics; Processing and function of biologically important macromolecules and complexes; Molecular basis of disease; RNA processing, structure and functions of non-coding RNAs, transcription; Sorting, spatiotemporal organization, trafficking; Structural biology; Synthetic biology; Translation, protein folding, chaperones, protein degradation and quality control.