评估全氟辛酸(PFOA)的皮肤吸收及其对其他全氟烷基和多氟烷基物质(PFAS)的影响。

IF 3 4区 医学 Q1 MEDICINE, LEGAL
Andrew Yeh, Robyn L Prueitt, Laura E Kerper, Barbara D Beck
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引用次数: 0

摘要

迄今为止,只有四项研究直接测量了人体皮肤中全氟辛酸(PFOA)的皮肤吸收动力学。报告的动力学参数跨越2到5个数量级,表明需要确定变异的原因,并确定最合适的皮肤吸收因子用于暴露评估。我们评估了测量PFOA分数吸收、稳态通量(Jss)和皮肤渗透系数(Kp)的研究的可靠性和生理相关性。我们验证了所报道的动力学参数是否在适当的条件下测量(即有限剂量条件下的分数吸收,无限剂量条件下的Jss和Kp)。我们推荐在皮肤、水溶液或相关消费品基质中测量的以下近似pH值作为PFOA暴露评估的临时值:有限剂量条件下1.6%的分数吸收,无限剂量条件下Jss和Kp分别为0.132 μg/cm2-hr和0.000044 cm/hr。使用推荐的吸收因子,我们估计了儿童通过皮肤和摄入途径从土壤和水中暴露的全氟辛酸。我们的研究结果表明,相对于摄入,PFOA的皮肤吸收率较低,并且对于物理化学性质与PFOA相似的全氟烷基和多氟烷基物质(PFAS)的皮肤吸收率也较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluating dermal absorption of perfluorooctanoic acid (PFOA) and implications for other per- and polyfluoroalkyl substances (PFAS).

To date, only four studies directly measured dermal absorption kinetics of perfluorooctanoic acid (PFOA) in human skin. Reported kinetic parameters spanned two to five orders of magnitude, demonstrating the need to determine the causes of variability and identify the most appropriate dermal absorption factors for use in exposure assessments. We evaluated the reliability and physiological relevance of studies that measured PFOA fractional absorption, steady-state flux (Jss), and dermal permeability coefficient (Kp). We verified whether the reported kinetic parameters were measured under appropriate conditions (i.e., fractional absorption under finite dose conditions, and Jss and Kp under infinite dose conditions). We recommend the following values measured at the approximate pH of the skin, and in aqueous solvents or relevant consumer product matrices, for use as provisional values in PFOA exposure assessments: 1.6% fractional absorption under finite dose conditions, and 0.132 μg/cm2-hr and 0.000044 cm/h for Jss and Kp, respectively, under infinite dose conditions. Using the recommended absorption factors, we estimated PFOA exposures in children from soil and water via dermal and ingestion routes. Our results indicate low dermal absorption of PFOA relative to ingestion, and low dermal absorption is expected for per- and polyfluoroalkyl substances (PFAS) with physicochemical properties similar to PFOA.

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来源期刊
CiteScore
6.70
自引率
8.80%
发文量
147
审稿时长
58 days
期刊介绍: Regulatory Toxicology and Pharmacology publishes peer reviewed articles that involve the generation, evaluation, and interpretation of experimental animal and human data that are of direct importance and relevance for regulatory authorities with respect to toxicological and pharmacological regulations in society. All peer-reviewed articles that are published should be devoted to improve the protection of human health and environment. Reviews and discussions are welcomed that address legal and/or regulatory decisions with respect to risk assessment and management of toxicological and pharmacological compounds on a scientific basis. It addresses an international readership of scientists, risk assessors and managers, and other professionals active in the field of human and environmental health. Types of peer-reviewed articles published: -Original research articles of relevance for regulatory aspects covering aspects including, but not limited to: 1.Factors influencing human sensitivity 2.Exposure science related to risk assessment 3.Alternative toxicological test methods 4.Frameworks for evaluation and integration of data in regulatory evaluations 5.Harmonization across regulatory agencies 6.Read-across methods and evaluations -Contemporary Reviews on policy related Research issues -Letters to the Editor -Guest Editorials (by Invitation)
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