分析 TGF-β 及其调节因子与宫颈癌的相关性,以确定治疗和诊断标记物。

IF 2.6 3区 生物学 Q2 GENETICS & HEREDITY
Gene Pub Date : 2024-12-18 DOI:10.1016/j.gene.2024.149166
Jayapradha Gnanagurusamy , Sneha Krishnamoorthy , Bharathi Muruganatham , Nagarajan Selvamurugan , Sridhar Muthusami
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引用次数: 0

摘要

转化生长因子-β (TGF-β)具有双重作用,在初期抑制肿瘤发展,在后期促进肿瘤转移。本研究旨在利用ONCODB和GEPIA数据库,分析不同类型TGF-β及其受体与宫颈癌(CC)患者总生存期(OS)和TGF-β驱动基因表达的相关性。基因表达分析显示,TGF-β1和TGF-β r2在人乳头瘤病毒(HPV)16感染细胞中表达上调,TGF-β2、TGF-β r1和TGF-β r3表达下调。在HPV 18感染细胞中,TGF-β1、TGF-β2、TGF-β r1下调,TGF-β3、TGF-β r2、TGF-β r3上调。对不同TGF-β表达的CC患者进行OS分析发现,TGF-β1、TGF-β2、TGF-β3、TGF-β r2与生存率降低相关。此外,我们使用MIENTURNET在HPV 16和18阳性样本中鉴定了四种microRNAs (miRNAs) (hsa-miR-21-5p, hsa-miR-29b-3p, hsa-miR-101-3p和hsa-miR-130a-3p)与TGF-β良好相互作用。本综述进一步强调,靶向TGF-β可能是一种新的、未来的CC管理和治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysing the relevance of TGF-β and its regulators in cervical cancer to identify therapeutic and diagnostic markers
The role of transforming growth factor-beta (TGF-β) is dual, such that, it inhibits tumor development in initial stage and promotes metastasis in later stage. The present study is aimed to analyse the relevance of different types of TGF-β and their receptors on the overall survival (OS) and TGF-β driven gene expression in individuals with cervical cancer (CC) using ONCODB and GEPIA databases. The in-silico gene expression analysis showed, TGF-β1 and TGFβR2 are upregulated in cells infected with human papilloma virus (HPV)16, whereas, TGF-β2, TGFβR1 and TGFβR3 expression were downregulated. In HPV 18 infected cells, TGF-β1, TGF-β2 and TGFβR1 were downregulated, meanwhile, TGF-β3, TGFβR2 and TGFβR3 were upregulated. OS analysis of CC patients with different TGF-β expression revealed that, TGF-β1, TGF-β2, TGF-β3 and TGFβR2 were associated with reduced survival rate. Further, we identified four microRNAs (miRNAs) (hsa-miR-21-5p, hsa-miR-29b-3p, hsa-miR-101-3p and hsa-miR-130a-3p) interacted favorably with TGF-β in HPV 16 and 18 positive samples using MIENTURNET. This present review further emphasizes that, targeting TGF-β could be a novel and futuristic approach for CC management and therapeutics.
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来源期刊
Gene
Gene 生物-遗传学
CiteScore
6.10
自引率
2.90%
发文量
718
审稿时长
42 days
期刊介绍: Gene publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses.
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