铜催化环二芳基鎓的双n -芳基化：5h -二苯并[d， f][1,3]二氮卓和苯并[c]喹啉衍生物的合成

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2024-09-30 DOI:10.1002/jhet.4914

Lianji Zhang, Yujuan Wu, Yuhui Zhao, Cuiping Wang, Wanguo Wei, Zhiqiang Zhang

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引用次数: 0

摘要

新的7元二苯二氮卓类和6元苯并[c]喹啉衍生物家族的有效途径已经详细阐述。该合成策略基于铜催化环二芳基碘鎓在环境反应条件下分别与咪酰胺和4-取代1,2,4 -三唑啉- 3,5 -二酮（TADs）进行双n -芳基化反应。讨论了双n -芳基化反应的机理。

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Practical Copper-Catalyzed Double N-Arylation of Cyclic Diaryliodoniums: Synthesis of 5H-Dibenzo[d, f][1,3]Diazepine, and Benzo[c]Cinnoline Derivatives

An efficient access to novel families of 7-membered dibenzodiazepines and 6-membered benzo[c]cinnoline derivatives has been elaborated. The synthetic strategy is based on a copper-catalyzed double N-arylation of cyclic diaryliodoniums with imidamides and 4-substituted 1, 2, 4-triazoline-3, 5-diones (TADs) respectively under ambient reaction conditions. A mechanistic rationale for the double N-arylation is discussed.

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来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.