结合土壤重金属形态及体外模型与人体肠道菌群的精确生物可及性评价

IF 6 3区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Guofeng Li, Haifeng Chi, Yanwei Hou, Paul N. Williams, Zhao Liu, Chao Cai
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引用次数: 0

摘要

Zn、Ni、Cd和Cu的生物可及性是准确评估与口腔接触重金属污染土壤相关的人类健康风险的关键参数。然而,大多数研究在评估这些金属的生物可及性时没有考虑金属化学分异和人体肠道微生物群的影响,而金属化学分异和人体肠道微生物群是影响重金属吸收的重要因素。在本研究中,采用改进的体外模型测定了Zn、Ni、Cd和Cu在土壤中的生物可及性。研究了重金属在无菌结肠相中的金属化学分异和生物可及性。结果表明,4种重金属的生物可及性均低于70%,表明单纯依靠总重金属浓度评价人体健康风险会导致高估。重金属的可交换性、与碳酸盐的结合、与铁和锰的结合(F123)接近其生物可及性。重金属在胃期的生物可及性与其F123值呈显著正相关(Zn、Ni和Cu的r分别为0.80、0.57和0.68),表明金属化学分异与生物可及性密切相关。与活性结肠期相比,Ni和Cd在无菌结肠期的生物可及性较高,而Cu在无菌结肠期的生物可及性较低。活性结肠和无菌结肠中重金属生物可及性的显著差异表明,体外人体肠道微生物群在肠道中重金属的吸附和解吸过程中起着关键作用。这些发现强调了在评估重金属的生物可及性及其相关健康风险时,同时考虑金属化学分馏和体外人体肠道微生物群的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Accurate bioaccessibility assessment of soil heavy metals by combining their speciation and in vitro model with human gut microbiota

The bioaccessibility of Zn, Ni, Cd, and Cu is a critical parameter for accurately assessing the human health risk associated with oral exposure to soils contaminated with heavy metals. However, most studies have evaluated the bioaccessibility of these metals without considering the impact of metallic chemical fractionations and human gut microbiota, which are important factors affecting the uptake of heavy metals. In this study, the bioaccessibility of Zn, Ni, Cd, and Cu in soils was measured in an improved in vitro model. The metallic chemical fractionations and bioaccessibility of heavy metals in the sterilized colon phase were also investigated. The results showed that the bioaccessibility of all four heavy metals was below 70%, indicating that relying solely on total metal concentration for assessing human health risks would result in overestimation. The exchangeable, bound to carbonates, and bound to iron and manganese fractions (F123) of heavy metals were found to be close to their bioaccessibility. Furthermore, the bioaccessibility of heavy metals in the gastric phase was strongly and positively correlated with their F123 values (r of Zn, Ni, and Cu were 0.80, 0.57, and 0.68, respectively), highlighting the close connection between metallic chemical fractionation and bioaccessibility. The bioaccessibility of Ni and Cd was found to be higher in the sterile colon phase compared to the active colon phase, whereas Cu showed lower bioaccessibility in the sterile colon phase. The significant differences in heavy metal bioaccessibility between the active and sterile colon suggested that human gut microbiota in vitro played a key role in the adsorption and desorption processes of heavy metals in the intestine. These findings underscore the importance of taking into account both metallic chemical fractionation and human gut microbiota in vitro when assessing the bioaccessibility of heavy metals and their associated health risks.

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来源期刊
Environmental Sciences Europe
Environmental Sciences Europe Environmental Science-Pollution
CiteScore
11.20
自引率
1.70%
发文量
110
审稿时长
13 weeks
期刊介绍: ESEU is an international journal, focusing primarily on Europe, with a broad scope covering all aspects of environmental sciences, including the main topic regulation. ESEU will discuss the entanglement between environmental sciences and regulation because, in recent years, there have been misunderstandings and even disagreement between stakeholders in these two areas. ESEU will help to improve the comprehension of issues between environmental sciences and regulation. ESEU will be an outlet from the German-speaking (DACH) countries to Europe and an inlet from Europe to the DACH countries regarding environmental sciences and regulation. Moreover, ESEU will facilitate the exchange of ideas and interaction between Europe and the DACH countries regarding environmental regulatory issues. Although Europe is at the center of ESEU, the journal will not exclude the rest of the world, because regulatory issues pertaining to environmental sciences can be fully seen only from a global perspective.
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