含多环片段的N，N ' -二取代脲及其等构类似物的合成与性能N - (Adamantane-1-carbonyl] - N ' - (haloaryl)硒脲

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2024-12-19 DOI:10.1134/S107042802410004X

Ya. P. Kuznetsov, D. A. Pitushkin, G. M. Butov

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引用次数: 0

摘要

以adaman - tan -1-羰基异硒氰酸酯和卤代苯胺为原料，以37 ~ 59%的产率合成了含卤代苯基片段的硒脲。用硒取代硫原子导致硒脲的熔点比它们的硫类似物降低了8-47°C。硅晶筛选表明，合成的硒脲最可能的生物活性类型是抑制人可溶性环氧化物水解酶和抗焦虑活性。

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Synthesis and Properties of N,N′-Disubstituted Ureas and Their Isosteric Analogues Containing Polycyclic Fragments: XXI. N-(Adamantane-1-carbonyl]-N′-(haloaryl)selenoureas

Selenoureas containing a halophenyl fragment were synthesized in 37–59% yields from adamantane-1-carbonyl isoselenocyanate and haloanilines. Replacement of the sulfur atom by selenium resulted in a reduction of the melting points of selenoureas by 8–47°C in comparison to their sulfur analogues. In silico screening showed that the most probable types of biological activity of the synthesized selenoureas are inhibition of human soluble epoxide hydrolase and anxiolytic activity.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.