戊酰吖啶酮生物碱及其类似物的合成及抗菌性能评价

Organic chemistry frontiers : an international journal of organic chemistry Pub Date : 2025-01-08 DOI:10.1039/d4qo02126f

Shilpi Karmakar , Kousik Maji , Sudeshna Mondal , Semantee Bhattacharya , Jyotirmayee Dash

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引用次数: 0

摘要

简明地全合成了天然炔吖啶酮生物碱、N-甲基环罂粟碱 A、N-甲基双叶芸香碱 D、双叶芸香碱 D、oriciacridone E、甘草次碱 II、正甘草次碱 II、3-O-甲氧基甘草次碱 II 及其具有不同功能的非天然类似物的新系列。对这些生物碱进行的抗菌测试表明，二氟甘草次碱 II 衍生物对链球菌的抗菌效力最高。

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Synthesis and antibacterial evaluation of prenylacridone alkaloids and their analogues†

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Synthesis and antibacterial evaluation of prenylacridone alkaloids and their analogues†

A concise total synthesis of natural prenylacridone alkaloids, N-methylcycloatalaphylline A, N-methylbuxifoliadine D, buxifoliadine D, oriciacridone E, glycocitrine II, norglycocitrine II, 3-O-methoxyglycocitrine II and a new series of their non-natural analogues with diverse functionalities is achieved. Antibacterial assays of these alkaloids revealed that the difluoro glycocitrine II derivative exhibits the highest potency against Streptococcus species.

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来源期刊

Organic chemistry frontiers : an international journal of organic chemistry

CiteScore

7.80

自引率

0.00%

发文量