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IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2024-12-20 DOI:10.1039/d4qo02126f

Shilpi Karmakara, Kousik Maji, Sudeshna Mondal, Semantee Bhattacharya, Jyotirmayee Dash

引用次数: 0

摘要

简明地全合成了天然炔吖啶酮生物碱、N-甲基环罂粟碱 A、N-甲基双叶芸香碱 D、双叶芸香碱 D、oriciacridone E、甘草次碱 II、正甘草次碱 II、3-O-甲氧基甘草次碱 II 及其具有不同功能的非天然类似物的新系列。对这些生物碱进行的抗菌测试表明，二氟甘草次碱 II 衍生物对链球菌的抗菌效力最高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis and Antibacterial Evaluation of Prenylacridone Alkaloids and Analogues

A concise total synthesis of natural prenylacridone alkaloids, N-methylcycloatalaphylline A, N-methylbuxifoliadine D, buxifoliadine D, oriciacridone E, glycocitrine II, norglycocitrine II, 3-O-methoxyglycocitrine II and new series of their non-natural analogues with diverse functionalities is achieved. Antibacterial assays of these alkaloids revealed that difluoro glycocitrine II derivative exhibits highest potency against Streptococcus species.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.