Palladium-catalyzed decarboxylative domino synthesis of fused quinolin-2(1H)-one scaffolds containing a perfluoroalkyl unit†

A novel palladium-catalyzed domino radical cyclization and C–H activation/decarboxylation of 1,7-enynes with o-bromobenzoic acids and perfluoroalkyl iodides has been developed for the expedited construction of fused perfluoroalkyl-containing quinolin-2(1H)-one scaffolds. This method provides a facile synthesis of fused quinolin-2(1H)-one derivatives containing a perfluoroalkyl unit in high yields. Notably, the late-stage modifications of various drugs were also demonstrated by using this method.