Tannaz Jamialahmadi, Željko Reiner, Luis E Simental-Mendia, Wael Almahmeed, Sercan Karav, Ali H Eid, Francesco Giammarile, Amirhossein Sahebkar
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引用次数: 0
摘要
背景：动脉粥样硬化的发病机制主要是由炎症过程介导的。他汀类药物是降脂药，也有抗炎作用。18氟放射性标记的氟脱氧葡萄糖（18 F-FDG）正电子发射断层扫描-计算机断层扫描（PET-CT）被认为是动脉壁炎症的良好指标。因此，在本荟萃分析中，他汀类药物对动脉壁炎症过程的作用使用这种方法进行评估，因为其在这一目的上的实际有效性尚未得到很好的确立。方法：采用MESH关键词检索PubMed、Scopus、Web of Science、ClinicalTrials.gov、谷歌Scholar等数据库。漏斗图、Begg’s秩相关检验和Egger’s加权回归检验评估meta分析中的发表偏倚。在观察到漏斗图不对称的情况下，使用“修剪和填充”方法来检查可能缺失的研究的输入。结果：10项涉及373名受试者的临床试验结果显示，根据目标-背景比（TBR）指数，他汀类药物治疗后动脉壁18 F-FDG摄取显著降低。亚组分析显示，高强度他汀类药物治疗可显著降低TBR，低至中等强度他汀类药物治疗可显著降低TBR。结论：18f - fdg PET-CT显示，他汀类药物治疗可抑制动脉壁炎症。
Effect of statins on arterial wall inflammation as assessed by 18F-FDG PET CT: an updated systematic review and meta-analysis.
Background: Pathogenesis of atherosclerosis is largely mediated by inflammatory process. Statins are lipid-lowering drugs which also have anti-inflammatory effects. 18 fluorine radiolabeled fluorodeoxyglucose (18 F-FDG) positron emission tomography-computed tomography (PET-CT) is considered to be a good indicator of arterial wall inflammation. Therefore, in this meta-analysis the role of statins on inflammatory process in the artery wall was evaluated using this method since its actual validity for this purpose is not yet well established.
Methods: PubMed, Scopus, Web of Science, ClinicalTrials.gov, and Google Scholar databases were searched using MESH terms and keywords. Funnel plot, Begg's rank correlation, and Egger's weighted regression tests evaluated publication bias in the meta-analysis. In cases where funnel plot asymmetry was observed, the "trim and fill" method was used to check the input of potentially missing studies.
Results: Findings of 10 clinical trials involving 373 subjects showed a remarkable reduction of arterial wall 18 F-FDG uptake according to target-to-background ratio (TBR) index after treatment with statins. Subgroup analysis showed a significant decrease in TBR with high-intensity and non-significant reduction of TBR with low-to-moderate-intensity statin therapy.
Conclusion: Treatment with statins suppressed arterial wall inflammation as shown by using 18 F-FDG PET-CT.
期刊介绍：
Journal of Inflammation welcomes research submissions on all aspects of inflammation.
The five classical symptoms of inflammation, namely redness (rubor), swelling (tumour), heat (calor), pain (dolor) and loss of function (functio laesa), are only part of the story. The term inflammation is taken to include the full range of underlying cellular and molecular mechanisms involved, not only in the production of the inflammatory responses but, more importantly in clinical terms, in the healing process as well. Thus the journal covers molecular, cellular, animal and clinical studies, and related aspects of pharmacology, such as anti-inflammatory drug development, trials and therapeutic developments. It also considers publication of negative findings.
Journal of Inflammation aims to become the leading online journal on inflammation and, as online journals replace printed ones over the next decade, the main open access inflammation journal. Open access guarantees a larger audience, and thus impact, than any restricted access equivalent, and increasingly so, as the escalating costs of printed journals puts them outside University budgets. The unrestricted access to research findings in inflammation aids in promoting dynamic and productive dialogue between industrial and academic members of the inflammation research community, which plays such an important part in the development of future generations of anti-inflammatory therapies.
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