Denis Ohlstrom, Zachary J Walker, Abhishek Pandey, Lorraine N Davis, Krysta L Engel, Zenggang Pan, Peter A Forsberg, Tomer M Mark, Austin E Gillen, Daniel W Sherbenou
{"title":"轻链逃逸前后的单细胞RNA测序揭示了患者内部具有不同溶骨基因表达的多发性骨髓瘤亚群。","authors":"Denis Ohlstrom, Zachary J Walker, Abhishek Pandey, Lorraine N Davis, Krysta L Engel, Zenggang Pan, Peter A Forsberg, Tomer M Mark, Austin E Gillen, Daniel W Sherbenou","doi":"10.1158/2767-9764.CRC-24-0170","DOIUrl":null,"url":null,"abstract":"<p><strong>Significance: </strong>scRNA-seq was used to study a patient with high-risk multiple myeloma featuring LCE. LCE was rooted in a transcriptomic subpopulation that corresponded to a genetic subclone and established novel links between LCE and LAMP5 overexpression to osteolysis and prognosis, validated in RNA-seq databases.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"106-118"},"PeriodicalIF":2.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737298/pdf/","citationCount":"0","resultStr":"{\"title\":\"Single-Cell RNA Sequencing before and after Light Chain Escape Reveals Intrapatient Multiple Myeloma Subpopulations with Divergent Osteolytic Gene Expression.\",\"authors\":\"Denis Ohlstrom, Zachary J Walker, Abhishek Pandey, Lorraine N Davis, Krysta L Engel, Zenggang Pan, Peter A Forsberg, Tomer M Mark, Austin E Gillen, Daniel W Sherbenou\",\"doi\":\"10.1158/2767-9764.CRC-24-0170\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Significance: </strong>scRNA-seq was used to study a patient with high-risk multiple myeloma featuring LCE. LCE was rooted in a transcriptomic subpopulation that corresponded to a genetic subclone and established novel links between LCE and LAMP5 overexpression to osteolysis and prognosis, validated in RNA-seq databases.</p>\",\"PeriodicalId\":72516,\"journal\":{\"name\":\"Cancer research communications\",\"volume\":\" \",\"pages\":\"106-118\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737298/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer research communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1158/2767-9764.CRC-24-0170\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer research communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1158/2767-9764.CRC-24-0170","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
Single-Cell RNA Sequencing before and after Light Chain Escape Reveals Intrapatient Multiple Myeloma Subpopulations with Divergent Osteolytic Gene Expression.
Significance: scRNA-seq was used to study a patient with high-risk multiple myeloma featuring LCE. LCE was rooted in a transcriptomic subpopulation that corresponded to a genetic subclone and established novel links between LCE and LAMP5 overexpression to osteolysis and prognosis, validated in RNA-seq databases.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
