钴催化环丙基二烯与炔/烯/烯的分子内[4 + 2]环加成反应及其机理

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-12-04 DOI:10.1021/acs.orglett.4c0377210.1021/acs.orglett.4c03772

Liyan Kan, Yi Zhou, Ling-Quan Kong and Zhi-Xiang Yu*,

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引用次数: 0

摘要

本文报道了一种钴催化的环丙基（CP）双烯与炔/烯/烯的分子内[4 + 2]环加成反应，为合成天然产物中常见的螺旋[2.5]辛烯环体系提供了一种有效的方法。[4 + 2]环加合物可通过CP化学转化为其他化合物。Ni也可以催化该反应。本文还报道了密度泛函理论对反应机理的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cobalt-Catalyzed Intramolecular [4 + 2] Cycloaddition of Cyclopropyl-Capped Dienes with Alkynes/Alkenes/Allene and Reaction Mechanism

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Cobalt-Catalyzed Intramolecular [4 + 2] Cycloaddition of Cyclopropyl-Capped Dienes with Alkynes/Alkenes/Allene and Reaction Mechanism

A cobalt-catalyzed intramolecular [4 + 2] cycloaddition of cyclopropyl (CP)-capped dienes with ynes/enes/allene was reported, providing an efficient method toward a spiro[2.5]octene ring system found in natural products, such as illudin. The [4 + 2] cycloadducts can be converted into other compounds via CP chemistry. This reaction can also be catalyzed by Ni. A density functional theory study on the reaction mechanisms is also reported here.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.