用 STK19 钥匙打开转录耦合 DNA 修复之门

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2024-12-19 DOI:10.1016/j.molcel.2024.11.027

Jochen Kuper, Caroline Kisker, Bennett Van Houten

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引用次数: 0

摘要

Ramadhin 等人1 在《分子细胞》（Molecular Cell）杂志上的一项研究以及 van den Heuvel 等人2 和 Mevissen 等人3 在《细胞》（Cell）杂志上的两项研究表明，STK19 是哺乳动物细胞中转录耦合核苷酸切除修复（TC-NER）的关键蛋白，它能介导初始修复蛋白复合物的形成和随后的 TFIIH 招募，从而实现重要的损伤验证步骤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Unlocking transcription-coupled DNA repair with the STK19 key

A study in Molecular Cell by Ramadhin et al.¹ and two studies in Cell by van den Heuvel et al.² and by Mevissen et al.³ show that STK19 is a key protein in transcription-coupled nucleotide excision repair (TC-NER) in mammalian cells by mediating the initial repair protein complex formation and subsequent TFIIH recruitment, thereby enabling the vital damage verification step.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.