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IF 3.6 3区医学 Q2 PHARMACOLOGY & PHARMACY

Pharmacopsychiatry Pub Date : 2024-12-17 DOI:10.1055/a-2479-9430

Tien-Wei Hsu, Shih-Jen Tsai, Tzeng-Ji Chen, Mu-Hong Chen, Chih-Sung Liang

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引用次数: 0

摘要

研究背景本研究旨在评估情感障碍患者罹患结直肠癌（CRC）的风险与接触情绪稳定剂、抗抑郁药和抗精神病药之间的关联：这项巢式病例对照研究使用的数据来自台湾国民健康保险数据库，收集时间为 2001 年至 2011 年。所有参与者均患有情感障碍。然后，根据人口统计学和临床特征，确定了 1209 名 CRC 患者和 1:10 匹配的对照组。研究采用逻辑回归模型，对人口统计学特征和临床特征进行调整，以确定暴露于精神药物后患上乳腺癌的风险：结果：在情感障碍患者中，与未接触过精神药物的患者相比，接触过情绪稳定剂（报告为几率比；95%置信区间；0.75；0.57-0.98）、抗抑郁剂（0.83；0.70-0.97）、第二代抗精神病药物（0.67；0.52-0.86）和第一代抗精神病药物（0.65；0.52-0.81）的患者患 CRC 的风险降低。在考虑特定药物时，卡马西平（0.34；0.12-0.95）、丙戊酸（0.66；0.46-0.95）、加巴喷丁（0.44；0.20-0.99）、氟西汀（0.82；0.68-0.99）、帕罗西汀（0.63；0.45-0.87）和文拉法辛（0.72；0.55-0.95）与较低的 CRC 风险相关：结论：与未接触精神药物的患者相比，情感障碍患者接触精神药物与较低的癌症风险有关。虽然不能直接推断出精神药物暴露与CRC风险降低之间的因果关系，但这些发现可能有助于临床医生和患者做出临床决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Exposure to Psychotropic Drugs and Colorectal Cancer Risk in Patients with Affective Disorder: A Nested Case-Control Study.

Background: This study aimed to assess the association between the risk of colorectal cancer (CRC) and exposure to mood stabilizers, antidepressants, and antipsychotics in patients with affective disorders.

Methods: This nested case-control study used data from the National Health Insurance Database of Taiwan collected between 2001 and 2011. All participants in this study had affective disorders. Then, 1209 patients with CRC and 1:10 matched controls were identified based on their demographic and clinical characteristics. A logistic regression model adjusted for demographic and clinical characteristics was used to determine the risk of developing CRC after exposure to psychotropic drugs.

Results: Among patients with affective disorders, exposure to mood stabilizers (reported as odds ratio; 95% confidence interval; 0.75; 0.57-0.98), antidepressants (0.83; 0.70-0.97), second-generation antipsychotics (0.67; 0.52-0.86), and first-generation antipsychotics (0.65; 0.52-0.81) were associated with a reduced risk of CRC compared to patients who were not exposed. When considering specific drugs, carbamazepine (0.34; 0.12-0.95), valproic acid (0.66; 0.46-0.95), gabapentin (0.44; 0.20-0.99), fluoxetine (0.82; 0.68-0.99), paroxetine (0.63; 0.45-0.87), and venlafaxine (0.72; 0.55-0.95) were associated with a lower risk of CRC.

Conclusion: Exposure to psychotropic drugs in patients with affective disorders is associated with a lower risk of CRC compared to those who were not exposed. Although the causal relationship between psychotropic drug exposure and reduced risk of CRC could not be inferred directly, these findings may help clinicians and patients in clinical decision-making.

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来源期刊

Pharmacopsychiatry 医学-精神病学

CiteScore

7.10

自引率

9.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Covering advances in the fi eld of psychotropic drugs, Pharmaco psychiatry provides psychiatrists, neuroscientists and clinicians with key clinical insights and describes new avenues of research and treatment. The pharmacological and neurobiological bases of psychiatric disorders are discussed by presenting clinical and experimental research.