IF 3.6 3区 生物学 Q3 CELL BIOLOGY
Najma Farahani, Mina Alimohammadi, Mehdi Raei, Noushin Nabavi, Amir Reza Aref, Kiavash Hushmandi, Salman Daneshi, Alireza Razzaghi, Afshin Taheriazam, Mehrdad Hashemi
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引用次数: 0

摘要

内质网(ER)对维持钙平衡、脂质生物合成和蛋白质折叠至关重要。内质网平衡的破坏通常是由于错误折叠或未折叠蛋白质的积累,从而导致内质网应激,这在各种疾病,尤其是癌症中起着重要作用。泌尿系统癌症是全球男性死亡率较高的疾病之一,由于其不可治愈性和产生耐药性的倾向,泌尿系统癌症一直是一项挑战。在众多失调的生物机制中,ER 应激是这些癌症进展和治疗反应的关键因素。本综述强调了ER应激异常激活在泌尿系统癌症中的双重作用,既影响肿瘤生长,也影响治疗效果。虽然ER应激可通过促进生存的自噬支持肿瘤生长,但它主要通过细胞凋亡和促进死亡的自噬抑制癌症进展。有趣的是,ER 应激可通过外泌体介导的免疫逃避等机制帮助癌症进展。此外,这篇综述还探讨了药物干预,特别是植物化学物质,如何能刺激ER应激介导的肿瘤抑制。还讨论了包括 PERK、IRE1α 和 ATF6 在内的关键调节因子在上调 CHOP 水平和触发细胞凋亡方面的作用。总之,深入了解泌尿系统癌症中的ER应激不仅能阐明细胞应激与癌症进展之间复杂的相互作用,还能为创新治疗策略提供新的机遇。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Exploring the dual role of endoplasmic reticulum stress in urological cancers: Implications for tumor progression and cell death interactions

Exploring the dual role of endoplasmic reticulum stress in urological cancers: Implications for tumor progression and cell death interactions

The endoplasmic reticulum (ER) is crucial for maintaining calcium balance, lipid biosynthesis, and protein folding. Disruptions in ER homeostasis, often due to the accumulation of misfolded or unfolded proteins, lead to ER stress, which plays a significant role in various diseases, especially cancer. Urological cancers, which account for high male mortality worldwide, pose a persistent challenge due to their incurability and tendency to develop drug resistance. Among the numerous dysregulated biological mechanisms, ER stress is a key factor in the progression and treatment response of these cancers. This review highlights the dual role of aberrant ER stress activation in urologic cancers, affecting both tumor growth and therapeutic outcomes. While ER stress can support tumor growth through pro-survival autophagy, it primarily inhibits cancer progression via apoptosis and pro-death autophagy. Interestingly, ER stress can paradoxically aid cancer progression through mechanisms such as exosome-mediated immune evasion. Additionally, the review examines how pharmacological interventions, particularly with phytochemicals, can stimulate ER stress-mediated tumor suppression. Key regulators, including PERK, IRE1α, and ATF6, are discussed for their roles in upregulating CHOP levels and triggering apoptosis. In conclusion, a deeper understanding of ER stress in urological cancers not only clarifies the complex interactions between cellular stress and cancer progression but also provides new opportunities for innovative therapeutic strategies.

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来源期刊
CiteScore
6.40
自引率
4.90%
发文量
40
期刊介绍: The Journal of Cell Communication and Signaling provides a forum for fundamental and translational research. In particular, it publishes papers discussing intercellular and intracellular signaling pathways that are particularly important to understand how cells interact with each other and with the surrounding environment, and how cellular behavior contributes to pathological states. JCCS encourages the submission of research manuscripts, timely reviews and short commentaries discussing recent publications, key developments and controversies. Research manuscripts can be published under two different sections : In the Pathology and Translational Research Section (Section Editor Andrew Leask) , manuscripts report original research dealing with celllular aspects of normal and pathological signaling and communication, with a particular interest in translational research. In the Molecular Signaling Section (Section Editor Satoshi Kubota) manuscripts report original signaling research performed at molecular levels with a particular interest in the functions of intracellular and membrane components involved in cell signaling.
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