致编辑的信：肿瘤与免疫相互作用的空间邻近性可预测肝细胞癌患者的预后。

IF 2.8 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Discover. Oncology Pub Date : 2024-12-18 DOI:10.1007/s12672-024-01666-x

Gaoyao Peng, Jiangfa Li, Xinchou Wang

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引用次数: 0

摘要

我们饶有兴趣地阅读了《肝脏学》上题为“肿瘤-免疫相互作用的空间邻近性预测患者肝细胞预后”的研究（Maestri E, Kedei N， Khatib S等人，《肝脏学》79(4):768- 779,2024）。本研究利用高复用CODEX成像技术，全面分析了肝细胞癌（HCC）中肿瘤与免疫细胞之间的空间相互作用，获得了一些有意义的发现，并创新性地提出了免疫细胞浸润的空间邻域概念，并证实了其与患者预后的关联。仔细阅读这篇文章后，我们有一些建议要指出来。

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Letter to the Editor: Spatial proximity of tumor-immune interactions predicts patient outcome in hepatocellular carcinoma.

We read with interest the study entitled "Spatial proximity of tumor-immune interactions predicts patient outcome in hepatocellular "in Hepatology (Maestri E, Kedei N, Khatib S, et al. in Hepatology 79(4):768-79, 2024). This study utilized highly multiplexed CODEX imaging to comprehensively analyze the spatial interactions between tumor and immune cells in hepatocellular carcinoma (HCC), yielding several meaningful findings and innovatively proposing the concept of the spatial neighborhood of immune cell infiltration and confirming its association with patient prognosis. After reading the article carefully, we have some suggestions to point out.

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