CAR-T细胞疗法治疗成人高级别胶质瘤

IF 6.8 1区医学 Q1 ONCOLOGY

NPJ Precision Oncology Pub Date : 2024-12-19 DOI:10.1038/s41698-024-00753-0

Sangwoo Park, Marcela V. Maus, Bryan D. Choi

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引用次数: 0

摘要

治疗恶性原发性脑肿瘤，包括胶质母细胞瘤，仍然是一个重大的挑战，尽管治疗进展。CAR-T细胞免疫疗法是一种很有前途的替代传统疗法。这篇综述讨论了CAR-T细胞治疗脑肿瘤的临床试验前景，强调了关键的进展，如新的靶抗原和旨在解决肿瘤异质性和免疫抑制的组合策略，目的是改善这些侵袭性癌症患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

CAR-T cell therapy for the treatment of adult high-grade gliomas

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CAR-T cell therapy for the treatment of adult high-grade gliomas

Treatment for malignant primary brain tumors, including glioblastoma, remains a significant challenge despite advances in therapy. CAR-T cell immunotherapy represents a promising alternative to conventional treatments. This review discusses the landscape of clinical trials for CAR-T cell therapy targeting brain tumors, highlighting key advancements like novel target antigens and combinatorial strategies designed to address tumor heterogeneity and immunosuppression, with the goal of improving outcomes for patients with these aggressive cancers.

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来源期刊

NPJ Precision Oncology ONCOLOGY-

CiteScore

9.90

自引率

1.30%

发文量

审稿时长

18 weeks

期刊介绍： Online-only and open access, npj Precision Oncology is an international, peer-reviewed journal dedicated to showcasing cutting-edge scientific research in all facets of precision oncology, spanning from fundamental science to translational applications and clinical medicine.