电化学C(sp3)-H功能化合成吡咯[1,2-a]喹啉类化合物

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2024-12-17 DOI:10.1039/D4QO01981D

Sijie Peng, Tong Li, Kai Li, Qi Sun and Zhiyong Wang

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引用次数: 0

摘要

在温和条件下，建立了一种高效的碘介导的C(sp3)-H电化学环化反应。利用该方法可制得多种功能化喹诺啉，收率高至优异。该反应具有底物范围广、产物分布规律好、制备规模大、原子经济性高等特点。详细探讨了反应机理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of pyrrolo[1,2-a]quinoxalines via an electrochemical C(sp3)–H functionalization†

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Synthesis of pyrrolo[1,2-a]quinoxalines via an electrochemical C(sp3)–H functionalization†

An efficient iodine-mediated electrochemical C(sp³)–H cyclization under mild conditions was developed. A variety of functionalized quinoxalines can be obtained with good to excellent yields by virtue of this method. The reaction was found to feature a broad substrate scope, regulation of product distribution, scalable preparation and high atom economy. The reaction mechanism was investigated in detail.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.