通过2-烯-4-炔酸酯的氢氟化获得氟化二烯

IF 4.6 1区 化学 Q1 CHEMISTRY, ORGANIC
Yue Xia, Aaron D. Charlack, Rui Guo, Nicholas W. Wade, Yiming Wang
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引用次数: 0

摘要

为合成含氟二烯,发展了炔的氢氟化反应。使用易于大规模制备的四氟硼酸吡啶盐,该方法能够通过乙烯基阳离子介导的过程将炔直接转化为氟化二烯目标。该方法应用于一系列芳基取代的烯酯,以提供具有高水平立体选择性和区域选择性的(Z)构型产物。进行了机理研究,以了解不同反应条件下的立体化学结果和反应效率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Access to Fluorinated Dienes through Hydrofluorination of 2-En-4-ynoates
The hydrofluorination of enynes has been developed for the synthesis of fluorinated dienes. Using a pyridinium tetrafluoroborate salt that is easily prepared on large scale, this approach enabled the direct conversion of enynes to fluorinated diene targets through a vinyl cation mediated process. This approach was applied to a range of aryl-substituted enyne esters to deliver the (Z)-configured products with high levels of stereo- and regioselectivity. Mechanistic studies were conducted to provide insights into the stereochemical outcome and reaction efficiency under different reaction conditions.
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来源期刊
Organic Chemistry Frontiers
Organic Chemistry Frontiers CHEMISTRY, ORGANIC-
CiteScore
7.90
自引率
11.10%
发文量
686
审稿时长
1 months
期刊介绍: Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.
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