Andreas A. Schönfeld, Jeff Hildreth, Alexandra Bourgouin, Veronika Flatten, Jakub Kozelka, William Simon, Andreas Schüller
{"title":"一种用于相对剂量测定和电子闪光放射治疗的光束导向的二维探测器阵列。","authors":"Andreas A. Schönfeld, Jeff Hildreth, Alexandra Bourgouin, Veronika Flatten, Jakub Kozelka, William Simon, Andreas Schüller","doi":"10.1002/mp.17573","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>FLASH radiotherapy is an emerging treatment modality using ultra-high dose rate beams. Much effort has been made to develop suitable dosimeters for reference dosimetry, yet the spatial beam characteristics must also be characterized to enable computerized treatment planning, as well as quality control and service of a treatment delivery device. In conventional radiation therapy, this is commonly achieved by beam profile scans in a water phantom using a point detector. In ultra-high dose rate beams, the delivered dose needed for a set of beam profile scans may exceed the regulatory dose limit specified for a typical treatment room, or degrade components of the scanning system and scanning detector. Point detector scans also cannot quantify the pulse-to-pulse stability of a beam profile. Detector arrays can overcome these challenges, but to date, no detector arrays suitable for ultra-high dose rate beams are commercially available.</p>\n </section>\n \n <section>\n \n <h3> Purpose</h3>\n \n <p>The study presents the development and characterization of a two-dimensional detector array for measuring pulse-resolved spatial fluence distributions in real-time and temporal structure of intra-pulse dose rate of ultra-high pulsed dose rate (UHPDR) electron beams used in FLASH radiotherapy.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The performance of the SunPoint 1 diode was evaluated by measuring the response of the EDGE Detector in a 20 MeV UHPDR electron beam with a dose per pulse of 0.04 Gy – 6 Gy at a pulse duration of 1 µs or 1.9 µs, and instantaneous dose rates of 0.040 – 3.2 MGy·s<sup>−1</sup>. Based on the findings regarding a suitable signal acquisition technique, a PROFILER 2 detector array made of SunPoint 1 diodes was then modified by minimizing trace resistance, applying a reverse bias, and implementing an RC component to each diode to optimize the transfer of the collected charge during a pulse. The resultant “FLASH Profiler” was then tested in the same UHPDR electron beam.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The FLASH Profiler exhibited a linear response within ± 3% deviation over the investigated dose per pulse range. The FLASH Profiler array showed good agreement with the absolute dose measured using a flashDiamond point detector and an integrating current transformer for dose-per-pulse values of up to 6 Gy. The FLASH Profiler was able to measure lateral beam profiles in real-time and on a single-pulse basis. The ability to capture and display the profiles during steering of UHPDR beams was demonstrated. The SunPoint 1 diode was able to measure the pulse duration and the intra-pulse dose rate with a time resolution of 4 ns.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The FLASH Profiler could be used for characterizing UHPDR electron beams and facilitating quality control and beam steering service of electron FLASH irradiators.</p>\n </section>\n </div>","PeriodicalId":18384,"journal":{"name":"Medical physics","volume":"52 3","pages":"1845-1857"},"PeriodicalIF":3.2000,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mp.17573","citationCount":"0","resultStr":"{\"title\":\"A 2D detector array for relative dosimetry and beam steering for FLASH radiotherapy with electrons\",\"authors\":\"Andreas A. 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Point detector scans also cannot quantify the pulse-to-pulse stability of a beam profile. Detector arrays can overcome these challenges, but to date, no detector arrays suitable for ultra-high dose rate beams are commercially available.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Purpose</h3>\\n \\n <p>The study presents the development and characterization of a two-dimensional detector array for measuring pulse-resolved spatial fluence distributions in real-time and temporal structure of intra-pulse dose rate of ultra-high pulsed dose rate (UHPDR) electron beams used in FLASH radiotherapy.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>The performance of the SunPoint 1 diode was evaluated by measuring the response of the EDGE Detector in a 20 MeV UHPDR electron beam with a dose per pulse of 0.04 Gy – 6 Gy at a pulse duration of 1 µs or 1.9 µs, and instantaneous dose rates of 0.040 – 3.2 MGy·s<sup>−1</sup>. Based on the findings regarding a suitable signal acquisition technique, a PROFILER 2 detector array made of SunPoint 1 diodes was then modified by minimizing trace resistance, applying a reverse bias, and implementing an RC component to each diode to optimize the transfer of the collected charge during a pulse. The resultant “FLASH Profiler” was then tested in the same UHPDR electron beam.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The FLASH Profiler exhibited a linear response within ± 3% deviation over the investigated dose per pulse range. The FLASH Profiler array showed good agreement with the absolute dose measured using a flashDiamond point detector and an integrating current transformer for dose-per-pulse values of up to 6 Gy. The FLASH Profiler was able to measure lateral beam profiles in real-time and on a single-pulse basis. The ability to capture and display the profiles during steering of UHPDR beams was demonstrated. The SunPoint 1 diode was able to measure the pulse duration and the intra-pulse dose rate with a time resolution of 4 ns.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>The FLASH Profiler could be used for characterizing UHPDR electron beams and facilitating quality control and beam steering service of electron FLASH irradiators.</p>\\n </section>\\n </div>\",\"PeriodicalId\":18384,\"journal\":{\"name\":\"Medical physics\",\"volume\":\"52 3\",\"pages\":\"1845-1857\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-12-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mp.17573\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/mp.17573\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical physics","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/mp.17573","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
A 2D detector array for relative dosimetry and beam steering for FLASH radiotherapy with electrons
Background
FLASH radiotherapy is an emerging treatment modality using ultra-high dose rate beams. Much effort has been made to develop suitable dosimeters for reference dosimetry, yet the spatial beam characteristics must also be characterized to enable computerized treatment planning, as well as quality control and service of a treatment delivery device. In conventional radiation therapy, this is commonly achieved by beam profile scans in a water phantom using a point detector. In ultra-high dose rate beams, the delivered dose needed for a set of beam profile scans may exceed the regulatory dose limit specified for a typical treatment room, or degrade components of the scanning system and scanning detector. Point detector scans also cannot quantify the pulse-to-pulse stability of a beam profile. Detector arrays can overcome these challenges, but to date, no detector arrays suitable for ultra-high dose rate beams are commercially available.
Purpose
The study presents the development and characterization of a two-dimensional detector array for measuring pulse-resolved spatial fluence distributions in real-time and temporal structure of intra-pulse dose rate of ultra-high pulsed dose rate (UHPDR) electron beams used in FLASH radiotherapy.
Methods
The performance of the SunPoint 1 diode was evaluated by measuring the response of the EDGE Detector in a 20 MeV UHPDR electron beam with a dose per pulse of 0.04 Gy – 6 Gy at a pulse duration of 1 µs or 1.9 µs, and instantaneous dose rates of 0.040 – 3.2 MGy·s−1. Based on the findings regarding a suitable signal acquisition technique, a PROFILER 2 detector array made of SunPoint 1 diodes was then modified by minimizing trace resistance, applying a reverse bias, and implementing an RC component to each diode to optimize the transfer of the collected charge during a pulse. The resultant “FLASH Profiler” was then tested in the same UHPDR electron beam.
Results
The FLASH Profiler exhibited a linear response within ± 3% deviation over the investigated dose per pulse range. The FLASH Profiler array showed good agreement with the absolute dose measured using a flashDiamond point detector and an integrating current transformer for dose-per-pulse values of up to 6 Gy. The FLASH Profiler was able to measure lateral beam profiles in real-time and on a single-pulse basis. The ability to capture and display the profiles during steering of UHPDR beams was demonstrated. The SunPoint 1 diode was able to measure the pulse duration and the intra-pulse dose rate with a time resolution of 4 ns.
Conclusion
The FLASH Profiler could be used for characterizing UHPDR electron beams and facilitating quality control and beam steering service of electron FLASH irradiators.
期刊介绍：
Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments
Medical Physics is a journal of global scope and reach. By publishing in Medical Physics your research will reach an international, multidisciplinary audience including practicing medical physicists as well as physics- and engineering based translational scientists. We work closely with authors of promising articles to improve their quality.
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