消化系统与糖尿病的交汇点:开拓新领域。

IF 4.2 3区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Asad Gul Rao, Abdulqadir J Nashwan
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Intersection of the glymphatic system and diabetes: Navigating a new frontier.

Diabetes is one of the most devastating medical dilemmas impacting every region of the world severely. The study by Tian et al investigates glymphatic system dysfunction in the context of glucose metabolism and diabetes, using diffusion tensor imaging along the perivascular space. The study evaluated individuals with type 2 diabetes mellitus (T2DM), prediabetes, and normal glucose metabolism. It found that prediabetic and T2DM groups had significantly impaired glymphatic function. Glymphatic dysfunction may serve as an early indicator of cognitive deterioration in diabetes due to the correlations shown between these abnormalities and clinical factors as well as cognitive performance. The study has some positives, such as thorough evaluations and novel imaging methods, but its cross-sectional design and limited sample size restrict its applicability. More extensive, long-term research is required to verify these results. Furthermore, there are significant clinical implications. Patients with diabetes may benefit from immediate therapies to prevent microvascular and macrovascular damage if glymphatic dysfunction is identified early. The study promotes comprehensive diabetes care with a focus on maintaining cognitive function. In conclusion, the work of Tian et al is crucial because it opens the door to better treatment and diagnostic strategies for diabetes-related cognitive deterioration.

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来源期刊
World Journal of Diabetes
World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
自引率
2.40%
发文量
909
期刊介绍: The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.
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