Insights into glymphatic system dysfunction and glucose continuum.

In this article, we comment on an original article published in a recent issue of the World Journal of Diabetes. That observational cross-sectional study focused on investigating the function of the glymphatic system and its clinical correlates in patients with different glucose metabolism states by using diffusion tensor imaging along the perivascular space (DTI-ALPS) index. It was shown that the cerebral glymphatic system may be dysfunctional in patients with type 2 diabetes. Various clinical variables affected the DTI-ALPS index in different glucose metabolism states. In conclusion, the study by Tian et al improves the understanding of the pathophysiology of diabetes-associated brain damage and provides insights for early diagnosis.