中老年男性2型糖尿病患者骨骼肌减少相关因素及其骨密度水平

IF 4.2 3区 医学 Q1 ENDOCRINOLOGY & METABOLISM
De-Qing Chen, Yong-Xin Wu, Ying-Xiao Zhang, Hai-Ling Yang, Huan-Huan Huang, Jiang-Yan Lv, Qian Xiao
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引用次数: 0

摘要

背景:慢性高血糖会损害微循环,损害各器官和组织的功能,使个体容易发生慢性并发症。肌肉减少症(SP)是与年龄相关的肌肉质量和功能下降,导致2型糖尿病的后遗症。特别是糖尿病患者,由于胰岛素抵抗、慢性炎症和体力活动减少,SP的风险更高。目的:探讨中老年男性2型糖尿病(T2DM)患者sp相关因素与骨密度(BMD)的关系。方法:回顾性分析2021年6月至2023年6月重庆医科大学第一附属医院住院的196例中老年男性2型糖尿病患者,以同期健康个体60例为对照组。比较两组患者一般信息、血液生化、糖化血红蛋白、肌力、SP检出率的差异。测定每位患者的骨密度(BMD)、阑尾骨骼肌(ASM)、脂肪量、握力和步态速度,并计算ASM指数(ASMI)。结果:196例中老年男性T2DM患者中有51例确诊为SP,占26.02%。合并SP的中老年T2DM患者病程较长,体重指数(BMI)和25(OH)D3均低于非SP患者。T2DM + SP患者的BMI、ASM、ASMI、左右握力、步态速度、上肢和下肢肌肉和脂肪量均低于糖尿病非SP患者。与非SP糖尿病患者相比,T2DM + SP患者的股骨颈、全髋关节和腰椎L1-4骨密度明显降低。长期糖尿病病程、低BMI、股骨颈、腰椎L1-4和全髋关节低BMD是SP发生的危险因素。结论:T2DM患者存在SP发生的危险;但是,可以采取措施预防相关的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sarcopenia-associated factors and their bone mineral density levels in middle-aged and elderly male type 2 diabetes patients.

Background: Chronic hyperglycemia can damage the microcirculation, which impairs the function of various organs and tissues and predisposes individuals to chronic complications. Sarcopenia (SP) is the age-related decline in muscle mass and function that contributes to the sequelae of type 2 diabetes. In particular, diabetic patients are at higher risk of SP because of insulin resistance, chronic inflammation, and decreased physical activity.

Aim: To identify SP-associated factors in middle-aged and elderly male type 2 diabetes mellitus (T2DM) patients and their correlation with bone mineral density (BMD).

Methods: A retrospective analysis was conducted on 196 middle-aged and elderly male T2DM inpatients in the First Affiliated Hospital of Chongqing Medical University between June 2021 and June 2023, with 60 concurrent healthy individuals as the control group. Differences in general information, blood biochemistry, glycosylated hemoglobin, muscle strength, and detection rate of SP were compared between groups. The BMD, appendicular skeletal muscle (ASM), and fat mass, as well as grip strength and gait speed, were determined for each patient, and the ASM index (ASMI) was counted. The quantitative data were subjected to correlation and logistic regression analyses to identify risk factors for SP.

Results: Fifty-one of the 196 middle-aged and elderly male T2DM patients were diagnosed with SP, which accounted for 26.02%. The middle-aged and elderly T2DM patients with SP exhibited a longer diabetes mellitus (DM) course and a lower body mass index (BMI) and 25(OH)D3 compared with the non-SP patients. The T2DM + SP patients exhibited lower BMI, ASM, ASMI, left- and right-hand grip strength, gait speed, and muscle and fat mass of the upper and lower limbs compared with the diabetic non-SP patients. The femoral neck, total hip, and lumbar spine L1-4 BMD were markedly lower in T2DM + SP patients compared with those in the non-SP diabetics. Long-term DM course, low BMI, and low BMD of the femoral neck, lumbar spine L1-4, and total hip were identified as risk factors for the development of SP.

Conclusion: T2DM patients are at risk for SP; however, measures can be taken to prevent the related risk factors.

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来源期刊
World Journal of Diabetes
World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
自引率
2.40%
发文量
909
期刊介绍: The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.
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