维生素 A 在儿童哮喘合并高血压中的作用:NHANES 数据库横断面研究。

IF 2.1 3区 医学 Q3 RESPIRATORY SYSTEM
Journal of thoracic disease Pub Date : 2024-11-30 Epub Date: 2024-11-21 DOI:10.21037/jtd-24-641
Ling Li, Shirui Zhu, Mei Xue
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引用次数: 0

摘要

背景:最近有研究报告称,膳食可调节风险因素与儿童代谢性疾病之间的关联。本研究旨在探讨膳食维生素 A(VA)在儿童和青少年哮喘合并高血压中的作用,并进一步提供预防哮喘相关高血压的膳食方面的信息:在这项横断面研究中,我们从美国国家健康与营养调查(NHANES)数据库中获得了9448名儿童和青少年的数据,时间跨度为2007年至2018年。采用加权单变量逻辑回归分析进行协变量筛选,并通过加权单变量和多变量逻辑回归分析探讨膳食VA和哮喘与高血压的关联。研究采用了带有 95% 置信区间(CI)的比值比(ORs)作为评价指标。此外,还对年龄、性别和体重指数(BMI)进行了分组分析:研究队列中共有 546 名高血压患者。经协变因素调整后,患有哮喘的儿童和青少年患高血压的几率高于非哮喘患者(OR =1.35,95% CI:1.03-1.78)。如果膳食中的维生素A摄入不足,与非哮喘患者相比,哮喘患者患高血压的几率明显更高(OR =1.46,95% CI:1.07-1.99)。此外,在年龄≥13 岁(OR =1.65,95% CI:1.21-2.26)、男性(OR =1.59,95% CI:1.09-2.33)和体重不足/体重正常(OR =1.97,95% CI:1.14-3.43)的亚组中,发现充足的膳食 VA 摄入量对高血压相关哮喘有潜在的有益影响:患有哮喘的儿童和青少年似乎患高血压的几率更高,而充足的膳食维生素A摄入量可能有助于降低哮喘相关高血压的风险。然而,膳食中VA摄入量对这种相关性的因果效应还需要进一步澄清。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of vitamin A in relation to childhood asthma with hypertension: a cross-sectional study of the NHANES database.

Background: Recent studies have reported that diet can modulate the associations between risk factors and childhood metabolic diseases. Herein, this study aims to explore the role of dietary vitamin A (VA) in relation to asthma with hypertension in children and adolescents, and further provide some information on dietary aspect for the prevention of asthma related hypertension.

Methods: In this cross-sectional study, data of 9,448 children and adolescents were obtained from the National Health and Nutrition Examination Survey (NHANES) database for the period of 2007 to 2018. Weighted univariate logistic regression analysis was used for covariates screening, and associations of dietary VA and asthma with hypertension were explored through weighted univariate and multivariate logistic regression analyses. Odds ratios (ORs) with 95% confidence intervals (CIs) were used as evaluation indexes. Besides, subgroup analyses of age, gender, and body mass index (BMI) were also performed.

Results: There were a total of 546 participants with hypertension in the study cohort. Children and adolescents with asthma had higher odds of hypertension than non-asthma individuals after covariates adjustment (OR =1.35, 95% CI: 1.03-1.78). When there were deficient dietary VA intakes, having asthma was significantly linked to higher odds of hypertension comparing to non-asthma individuals (OR =1.46, 95% CI: 1.07-1.99). Additionally, the potential beneficial effect of sufficient dietary VA intakes on hypertension related asthma was found in aged ≥13 years old (OR =1.65, 95% CI: 1.21-2.26), male (OR =1.59, 95% CI: 1.09-2.33), and underweight/normal weight (OR =1.97, 95% CI: 1.14-3.43) subgroups.

Conclusions: Children and adolescents having asthma seemed to have higher odds of hypertension, and sufficient dietary VA intakes may help reduce the risk of asthma related hypertension. However, the causal effect of dietary VA intakes on this correlation needs further clarification.

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来源期刊
Journal of thoracic disease
Journal of thoracic disease RESPIRATORY SYSTEM-
CiteScore
4.60
自引率
4.00%
发文量
254
期刊介绍: The Journal of Thoracic Disease (JTD, J Thorac Dis, pISSN: 2072-1439; eISSN: 2077-6624) was founded in Dec 2009, and indexed in PubMed in Dec 2011 and Science Citation Index SCI in Feb 2013. It is published quarterly (Dec 2009- Dec 2011), bimonthly (Jan 2012 - Dec 2013), monthly (Jan. 2014-) and openly distributed worldwide. JTD received its impact factor of 2.365 for the year 2016. JTD publishes manuscripts that describe new findings and provide current, practical information on the diagnosis and treatment of conditions related to thoracic disease. All the submission and reviewing are conducted electronically so that rapid review is assured.
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