关于 Elovl6 在人类疾病中作用的新见解:治疗挑战与机遇

IF 5.2 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Jiao Guo, Shulan Xue, Xiaohui Wang, Li Wang, Shi-Yuan Wen
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引用次数: 0

摘要

ELOVL6,超长链脂肪酸延长酶,脂质代谢中的关键酶,主要负责C12-C16饱和脂肪酸碳链的延长。它在各种人类疾病中发挥着重要作用,特别是那些与脂肪酸合成相关的代谢紊乱,如胰岛素抵抗、非酒精性脂肪性肝病、癌症和心血管疾病。新兴研究还将ELOVL6与肾脏疾病、癫痫等神经系统疾病和肺纤维化联系起来。这种酶的表达受多种因素的调控,包括饮食、氧化应激和昼夜节律。例如,高碳水化合物饮食可以促进ELOVL6表达的增加。这种异常导致长链脂肪酸的积累和脂质沉积,最终导致身体多个系统的病理后果。作为一种生物靶点,ELOVL6有望在诊断和治疗方面应用,未来的研究有望揭示其机制和治疗潜力,为多种疾病领域的新干预措施铺平道路。现就ELOVL6在人类各种疾病中的表达调控及功能进行综述。这篇综述强调了ELOVL6作为人类疾病的重要治疗靶点,其诊断和治疗应用的潜力有望推动未来的研究,并使各种病理条件的创新干预成为可能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Emerging insights on the role of Elovl6 in human diseases: Therapeutic challenges and opportunities

Emerging insights on the role of Elovl6 in human diseases: Therapeutic challenges and opportunities
ELOVL6, elongation-of-very-long-chain-fatty acids 6, a crucial enzyme in lipid metabolism, primarily responsible for the elongation of carbon chains of C12-C16 saturated fatty acids. It plays a significant role in various human diseases, particularly those associated with metabolic disorders related to fatty acid synthesis, such as insulin resistance, non-alcoholic fatty liver disease, cancer, and cardiovascular diseases. Emerging research also links ELOVL6 to kidney diseases, neurological conditions such as epilepsy, and pulmonary fibrosis. The enzyme's expression is regulated by various factors including diet, oxidative stress, and circadian rhythms. For instance, a high-carbohydrate diet can promote an increase in ELOVL6 expression. This abnormality leads to an accumulation of long-chain fatty acids and lipid deposition, ultimately resulting in pathological consequences across multiple systems in the body. As a biological target, ELOVL6 holds promise for diagnostic and therapeutic applications, with future research expected to uncover its mechanisms and therapeutic potential, paving the way for novel interventions in multiple disease areas. Here, the expression regulation and function of ELOVL6 in various human diseases are reviewed. This review underscores ELOVL6 as a significant therapeutic target for human diseases, with its potential for diagnostic and therapeutic applications anticipated to drive future research and enable innovative interventions in various pathological conditions.
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来源期刊
Life sciences
Life sciences 医学-药学
CiteScore
12.20
自引率
1.60%
发文量
841
审稿时长
6 months
期刊介绍: Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.
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