{"title":"NSTEMI 老年患者的介入治疗与保守治疗--SENIOR-RITA 试验的启示。","authors":"Pradeep Narayan","doi":"10.1007/s12055-024-01877-5","DOIUrl":null,"url":null,"abstract":"<p><p>The SENIOR-RITA trial randomized 1,518 elderly Non-ST-segment elevation myocardial infarction (NSTEMI) patients to invasive or conservative strategies. The primary composite outcome of cardiovascular death or nonfatal Myocardial Infarction (MI) occurred in 25.6% of the invasive group versus 26.3% in the conservative group (p = 0.53), despite lower nonfatal MI rates with invasive treatment (11.7% vs 15.0%). Procedural complications were low (< 1%), though the invasive group had slightly higher bleeding and Transient Ischemic Attack (TIA) rates. The early 1-year benefit of the invasive approach was not maintained at 5 years, highlighting the need to individualize management in this complex, elderly population. The review discusses the strengths and weaknesses of the SENIOR-RITA (Older Patients with Non-ST-Segment Elevation Myocardial Infarction Randomized Interventional Treatment) trial.</p>","PeriodicalId":13285,"journal":{"name":"Indian Journal of Thoracic and Cardiovascular Surgery","volume":"41 1","pages":"80-82"},"PeriodicalIF":0.7000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638419/pdf/","citationCount":"0","resultStr":"{\"title\":\"Invasive vs conservative management in elderly patients with NSTEMI- insights from the SENIOR-RITA trial.\",\"authors\":\"Pradeep Narayan\",\"doi\":\"10.1007/s12055-024-01877-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The SENIOR-RITA trial randomized 1,518 elderly Non-ST-segment elevation myocardial infarction (NSTEMI) patients to invasive or conservative strategies. The primary composite outcome of cardiovascular death or nonfatal Myocardial Infarction (MI) occurred in 25.6% of the invasive group versus 26.3% in the conservative group (p = 0.53), despite lower nonfatal MI rates with invasive treatment (11.7% vs 15.0%). Procedural complications were low (< 1%), though the invasive group had slightly higher bleeding and Transient Ischemic Attack (TIA) rates. The early 1-year benefit of the invasive approach was not maintained at 5 years, highlighting the need to individualize management in this complex, elderly population. The review discusses the strengths and weaknesses of the SENIOR-RITA (Older Patients with Non-ST-Segment Elevation Myocardial Infarction Randomized Interventional Treatment) trial.</p>\",\"PeriodicalId\":13285,\"journal\":{\"name\":\"Indian Journal of Thoracic and Cardiovascular Surgery\",\"volume\":\"41 1\",\"pages\":\"80-82\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638419/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Thoracic and Cardiovascular Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s12055-024-01877-5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Thoracic and Cardiovascular Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12055-024-01877-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/2 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Invasive vs conservative management in elderly patients with NSTEMI- insights from the SENIOR-RITA trial.
The SENIOR-RITA trial randomized 1,518 elderly Non-ST-segment elevation myocardial infarction (NSTEMI) patients to invasive or conservative strategies. The primary composite outcome of cardiovascular death or nonfatal Myocardial Infarction (MI) occurred in 25.6% of the invasive group versus 26.3% in the conservative group (p = 0.53), despite lower nonfatal MI rates with invasive treatment (11.7% vs 15.0%). Procedural complications were low (< 1%), though the invasive group had slightly higher bleeding and Transient Ischemic Attack (TIA) rates. The early 1-year benefit of the invasive approach was not maintained at 5 years, highlighting the need to individualize management in this complex, elderly population. The review discusses the strengths and weaknesses of the SENIOR-RITA (Older Patients with Non-ST-Segment Elevation Myocardial Infarction Randomized Interventional Treatment) trial.
期刊介绍：
The primary aim of the Indian Journal of Thoracic and Cardiovascular Surgery is education. The journal aims to dissipate current clinical practices and developments in the area of cardiovascular and thoracic surgery. This includes information on cardiovascular epidemiology, aetiopathogenesis, clinical manifestation etc. The journal accepts manuscripts from cardiovascular anaesthesia, cardiothoracic and vascular nursing and technology development and new/innovative products.The journal is the official publication of the Indian Association of Cardiovascular and Thoracic Surgeons which has a membership of over 1000 at present.DescriptionThe journal is the official organ of the Indian Association of Cardiovascular-Thoracic Surgeons. It was started in 1982 by Dr. Solomon Victor and ws being published twice a year up to 1996. From 2000 the editorial office moved to Delhi. From 2001 the journal was extended to quarterly and subsequently four issues annually have been printed out at time and regularly without fail. The journal receives manuscripts from members and non-members and cardiovascular surgeons. The manuscripts are peer reviewed by at least two or sometimes three or four reviewers who are on the panel. The manuscript process is now completely online. Funding the journal comes partially from the organization and from revenue generated by subscription and advertisement.
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