因良性适应症而接受子宫切除术或子宫肌瘤切除术的妇女中隐匿性恶性肿瘤的发生率以及切除术对生存结果的影响:一项荟萃分析。

IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Dan Jiang, Hongxuan Liu, Kui Huang, Yan Chen, Qiao Liu, Chuqiang Shu, Qi Tian
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Pooled HR analysis revealed that chemotherapy significantly improved PFS (HR: 0.49; 95% CI: 0.32-0.77; p = 0.002) and OS (HR: 0.49; 95% CI: 0.28-0.87; p = 0.015). Conclusions The incidence of occult malignancies in women undergoing hysterectomy or myomectomy for benign conditions is approximately 2.88 per 1,000 individuals. Morcellation does not impact survival outcomes, whereas adjuvant chemotherapy provides a survival benefit. 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引用次数: 0

摘要

本文章由计算机程序翻译,如有差异,请以英文原文为准。
The prevalence of occult malignancy in women undergoing hysterectomy or myomectomy for benign indications and the impact of morcellation on survival outcomes: a meta-analysis.

Introduction Uterine fibroids (UFs), also known as leiomyomas, are the most common benign gynecological tumors. Currently, morcellation is discouraged owing to the risk of disseminating undetected malignancies. This study aims to update the prevalence data on occult malignancies in surgeries for suspected benign uterine lesions and analyze the impact of treatment strategies on survival outcomes in patients with occult malignancies. Methods Five English-language literature databases were systematically searched up to July 25, 2024, for studies reporting the incidence of occult malignancies in patients with suspected UFs and their survival outcomes. The study was preregistered on PROSPERO(CRD42024580233). Results A total of 34 studies were included in the analysis. The pooled incidence of occult malignancies, calculated via a random effects model, was 2.88 (2.10-3.94) per 1,000 individuals. Significant regional variations were observed in the subgroup comparisons (p<0.01). Moreover, morcellation did not significantly affect progression-free survival (PFS) (hazard ratio [HR]: 1.26, 95% CI: 0.86 - 1.84, p = 0.240) or overall survival (OS) (HR: 1.13, 95% CI: 0.70 - 1.82, p = 0.614). Pooled HR analysis revealed that chemotherapy significantly improved PFS (HR: 0.49; 95% CI: 0.32-0.77; p = 0.002) and OS (HR: 0.49; 95% CI: 0.28-0.87; p = 0.015). Conclusions The incidence of occult malignancies in women undergoing hysterectomy or myomectomy for benign conditions is approximately 2.88 per 1,000 individuals. Morcellation does not impact survival outcomes, whereas adjuvant chemotherapy provides a survival benefit. Further well-designed clinical trials are needed to validate these findings.

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来源期刊
CiteScore
4.20
自引率
4.80%
发文量
44
审稿时长
6-12 weeks
期刊介绍: This journal covers the most active and promising areas of current research in gynecology and obstetrics. Invited, well-referenced reviews by noted experts keep readers in touch with the general framework and direction of international study. Original papers report selected experimental and clinical investigations in all fields related to gynecology, obstetrics and reproduction. Short communications are published to allow immediate discussion of new data. The international and interdisciplinary character of this periodical provides an avenue to less accessible sources and to worldwide research for investigators and practitioners.
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