美克丽嗪晕船药及其对小鼠模型中枢神经系统氧毒性的影响。

IF 0.8 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Guy Wiener, Anna Jamison, Dror Tal
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引用次数: 0

摘要

介绍:潜水利用闭路纯氧换气系统已成为流行的专业设置。氧气潜水员面临的危险之一是中枢神经系统氧中毒(CNS-OT),可能导致致命的抽搐。同时,潜水员经常乘船旅行,经常晕船。非处方药物美舒利嗪是一种抗胆碱能和抗组胺能药物,在治疗晕船方面很受欢迎。有报道表明乙酰胆碱对谷氨酸有抑制作用,谷氨酸是导致CNS-OT发作机制的主要成分。本研究的目的是测试在高压氧条件下美利嗪对CNS-OT发作潜伏期的影响。方法:采用随机交叉设计,将20只雄性小鼠分别给予对照溶液(羧甲基纤维素溶剂)或药物溶液(美氯嗪),两次暴露于608 kPa(6个大气压)的绝对压力下,同时呼吸氧气。视觉测量强直阵挛发作潜伏期。结果:对照组(414秒,标准差[SD] 113秒)和美氯嗪组(434秒,标准差[SD] 174秒)的平均癫痫发作潜伏期无显著差异。结论:基于该动物模型的结果,美氯嗪可能是患有晕船的潜水员的合适选择,他们计划使用纯氧再呼吸系统潜水。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Meclizine seasickness medication and its effect on central nervous system oxygen toxicity in a murine model.

Introduction: Diving utilising closed circuit pure oxygen rebreather systems has become popular in professional settings. One of the hazards the oxygen diver faces is central nervous system oxygen toxicity (CNS-OT), causing potentially fatal convulsions. At the same time, divers frequently travel by boat, often suffering seasickness. The over-the-counter medication meclizine is an anticholinergic and antihistaminergic agent that has gained popularity in the treatment of seasickness. Reports have shown the inhibitory effect that acetylcholine has on glutamate, a main component in the mechanism leading to CNS-OT seizure. The goal of the present study was to test the effect of meclizine on the latency to CNS-OT seizures under hyperbaric oxygen conditions.

Methods: Twenty male mice were exposed twice to 608 kPa (6 atmospheres) absolute pressure while breathing oxygen after administration of control solution (carboxymethyl cellulose solvent) or drug solution (meclizine) in a randomised crossover design. Latency to tonic-clonic seizures was visually measured.

Results: Mean latency to seizure did not significantly differ between the control group (414 s, standard deviation [SD] 113 s) and meclizine group (434 s, SD 174 s).

Conclusions: Based on results from this animal model, meclizine may be an appropriate option for divers suffering from seasickness, who plan on diving using pure oxygen rebreather systems.

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来源期刊
Diving and hyperbaric medicine
Diving and hyperbaric medicine 医学-公共卫生、环境卫生与职业卫生
CiteScore
1.70
自引率
22.20%
发文量
37
审稿时长
>12 weeks
期刊介绍: Diving and Hyperbaric Medicine (DHM) is the combined journal of the South Pacific Underwater Medicine Society (SPUMS) and the European Underwater and Baromedical Society (EUBS). It seeks to publish papers of high quality on all aspects of diving and hyperbaric medicine of interest to diving medical professionals, physicians of all specialties, scientists, members of the diving and hyperbaric industries, and divers. Manuscripts must be offered exclusively to Diving and Hyperbaric Medicine, unless clearly authenticated copyright exemption accompaniesthe manuscript. All manuscripts will be subject to peer review. Accepted contributions will also be subject to editing.
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