[Influence of tooth extraction on the CT level in plasma. Influence on the plasma Ca-P levels during the postextraction healing after CT administration].

The constant concentration of calcium ions (Ca2+) in the extracellular fluids can be maintained by two mechanisms; the local and the hormonal one. In the case of the local, a potential Ca2+ balance is achieved between the extracellular space on the one hand and the bones and intertine on the other hand, which may come to concentrations of 7 mg/100 ml. The complete settlement of the Ca2+ level up to the normal limits of 9-11 mg/100 ml of plasma, is achieved by the action of the hormonal mechanism. This acts through a negative ruccessive muctual control. The hormonal mechanism includes the action of basically two hormones, the parathormone (PTH) and the calcitonine (CT). The first one is secreted when the Ca2+ level in plasma decreases, causing the increase of the renal tubular reabsorption of Ca2+, the release of Ca2+, due to the increased absorption in bones and the increased intestinal Ca2+ absorption. By that way the Ca2+ normal level in plasma is resettled. On the other hand, in case of an increase of the Ca2+ level in plasma, the excretion of PTH is restrained whereas CT is secreted, which favours the deposition of Ca2+ on bones restricting their absorption at the same time. In several cases, when there is an organic inability of resettling any change of the Ca2+ balance due to the malfunction of the hormonal mechanism, various drugs are being given for treating the disease. The balance, being achieved this way, may be overtured by several factors such as bone fractures as it has been observed experimentally, and may cause the increase of the Ca2+ concentration in plasma. In the present experimental study, the possibility of a proportional increase in the secretion of the CT after a simple and surgical extraction has been investigated. The possibility of an alteration of the Calcium and Posphate levels in plasma after the supply of CT during certain intervals has also been investigated. The results showed that the extraction does not change the CT levels in plasma. On the other hand the Ca2+ and P levels, are not affected by the external supply of CT, for reasons which are being discussed in the present paper.