探索线粒体在放射治疗中的作用和应用。

IF 4.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2024-12-12 DOI:10.1016/j.bbadis.2024.167623

Yi Ding , Wang Jing , Zhichao Kang , Zhe Yang

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引用次数: 0

摘要

线粒体在细胞能量代谢、氧化应激反应和细胞凋亡中起关键作用。最近的研究集中在利用它们的功能来提高放射治疗（RT）的疗效。本文综述了线粒体在放射治疗中的重要功能和应用，包括靶向线粒体代谢和线粒体介导的细胞死亡和免疫反应的调节。虽然这些策略在临床前研究中显示出改善放射治疗结果的巨大潜力，但仍然存在挑战，例如优化药物输送系统，确保安全性和克服对治疗的耐药性。

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Exploring the role and application of mitochondria in radiation therapy

Mitochondria are pivotal in cellular energy metabolism, the oxidative stress response and apoptosis. Recent research has focused on harnessing their functions to enhance the efficacy of radiation therapy (RT). This review focuses on the critical functions and applications of mitochondria in radiation therapy, including the targeting of mitochondrial metabolism and the modulation of mitochondria-mediated cell death and immune responses. While these strategies have demonstrated considerable potential in preclinical studies to improve radiotherapy outcomes, challenges remain, such as optimizing drug delivery systems, ensuring safety and overcoming resistance to therapy.

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来源期刊

Biochimica et biophysica acta. Molecular basis of disease 生物-生化与分子生物学

CiteScore

12.30

自引率

0.00%

发文量

218

审稿时长

32 days

期刊介绍： BBA Molecular Basis of Disease addresses the biochemistry and molecular genetics of disease processes and models of human disease. This journal covers aspects of aging, cancer, metabolic-, neurological-, and immunological-based disease. Manuscripts focused on using animal models to elucidate biochemical and mechanistic insight in each of these conditions, are particularly encouraged. Manuscripts should emphasize the underlying mechanisms of disease pathways and provide novel contributions to the understanding and/or treatment of these disorders. Highly descriptive and method development submissions may be declined without full review. The submission of uninvited reviews to BBA - Molecular Basis of Disease is strongly discouraged, and any such uninvited review should be accompanied by a coverletter outlining the compelling reasons why the review should be considered.