Jiajia Wang, Yi Yang, An Song, Yingying Chen, Yan Jiang, Mei Li, Xiaoping Xing, Weibo Xia, Ou Wang
{"title":"假性甲状旁腺功能减退症患者的骨显微结构和骨强度","authors":"Jiajia Wang, Yi Yang, An Song, Yingying Chen, Yan Jiang, Mei Li, Xiaoping Xing, Weibo Xia, Ou Wang","doi":"10.1007/s00223-024-01313-1","DOIUrl":null,"url":null,"abstract":"<p><p>The present study aimed to assess bone strength and microstructure in patients with pseudohypoparathyroidism (PHP), nonsurgical HP (NS-HP), and healthy controls. A total of 54 PHP1 patients (14 PHP1a, 40 PHP1b), 54 age-/sex- matched NS-HP patients and 27 age-/sex-matched controls were enrolled. Clinical characteristics, biochemical indices and HR-pQCT indices were respectively collected. PHP1 patients had higher serum Ca and PTH level than NS-HP patients at the time of both diagnosis and HR-pQCT measurement. A higher BMI and lower serum P level were observed in PHP1 patients than NS-HP patients at the time of HR-pQCT measurement. Bone microstructure analysis showed PHP1 patients had decreased Tb.N, increased Tb.Sp, and increased Tb.1/N.SD at tibia compared to NS-HP patients. Subgroup analysis showed no significant difference in Tb.N and Tb.Sp in PHP1b patients compared to NS-HP patients. Multiple linear regression analysis showed increased Tb.N and decreased Tb.Sp at tibia were associated with longer treatment duration in PHP1b patients. The microarchitecture evaluated by HR-pQCT in this study further supported that bone tissue had a preserved sensitivity to PTH in PHP1 patients and trabecular bone was more susceptible. Moreover, at least, bone status in PHP1b patients might benefit from regular treatment.</p>","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"4"},"PeriodicalIF":3.3000,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Bone Microstructure and Bone Strength Among Patients with Pseudohypoparathyroidism.\",\"authors\":\"Jiajia Wang, Yi Yang, An Song, Yingying Chen, Yan Jiang, Mei Li, Xiaoping Xing, Weibo Xia, Ou Wang\",\"doi\":\"10.1007/s00223-024-01313-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The present study aimed to assess bone strength and microstructure in patients with pseudohypoparathyroidism (PHP), nonsurgical HP (NS-HP), and healthy controls. A total of 54 PHP1 patients (14 PHP1a, 40 PHP1b), 54 age-/sex- matched NS-HP patients and 27 age-/sex-matched controls were enrolled. Clinical characteristics, biochemical indices and HR-pQCT indices were respectively collected. PHP1 patients had higher serum Ca and PTH level than NS-HP patients at the time of both diagnosis and HR-pQCT measurement. A higher BMI and lower serum P level were observed in PHP1 patients than NS-HP patients at the time of HR-pQCT measurement. Bone microstructure analysis showed PHP1 patients had decreased Tb.N, increased Tb.Sp, and increased Tb.1/N.SD at tibia compared to NS-HP patients. Subgroup analysis showed no significant difference in Tb.N and Tb.Sp in PHP1b patients compared to NS-HP patients. Multiple linear regression analysis showed increased Tb.N and decreased Tb.Sp at tibia were associated with longer treatment duration in PHP1b patients. The microarchitecture evaluated by HR-pQCT in this study further supported that bone tissue had a preserved sensitivity to PTH in PHP1 patients and trabecular bone was more susceptible. Moreover, at least, bone status in PHP1b patients might benefit from regular treatment.</p>\",\"PeriodicalId\":9601,\"journal\":{\"name\":\"Calcified Tissue International\",\"volume\":\"116 1\",\"pages\":\"4\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-12-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Calcified Tissue International\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00223-024-01313-1\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Calcified Tissue International","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00223-024-01313-1","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Bone Microstructure and Bone Strength Among Patients with Pseudohypoparathyroidism.
The present study aimed to assess bone strength and microstructure in patients with pseudohypoparathyroidism (PHP), nonsurgical HP (NS-HP), and healthy controls. A total of 54 PHP1 patients (14 PHP1a, 40 PHP1b), 54 age-/sex- matched NS-HP patients and 27 age-/sex-matched controls were enrolled. Clinical characteristics, biochemical indices and HR-pQCT indices were respectively collected. PHP1 patients had higher serum Ca and PTH level than NS-HP patients at the time of both diagnosis and HR-pQCT measurement. A higher BMI and lower serum P level were observed in PHP1 patients than NS-HP patients at the time of HR-pQCT measurement. Bone microstructure analysis showed PHP1 patients had decreased Tb.N, increased Tb.Sp, and increased Tb.1/N.SD at tibia compared to NS-HP patients. Subgroup analysis showed no significant difference in Tb.N and Tb.Sp in PHP1b patients compared to NS-HP patients. Multiple linear regression analysis showed increased Tb.N and decreased Tb.Sp at tibia were associated with longer treatment duration in PHP1b patients. The microarchitecture evaluated by HR-pQCT in this study further supported that bone tissue had a preserved sensitivity to PTH in PHP1 patients and trabecular bone was more susceptible. Moreover, at least, bone status in PHP1b patients might benefit from regular treatment.
期刊介绍:
Calcified Tissue International and Musculoskeletal Research publishes original research and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms and clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions.