假性甲状旁腺功能减退症患者的骨显微结构和骨强度

IF 3.3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Jiajia Wang, Yi Yang, An Song, Yingying Chen, Yan Jiang, Mei Li, Xiaoping Xing, Weibo Xia, Ou Wang
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引用次数: 0

摘要

本研究旨在评估假性甲状旁腺功能减退症(PHP)、非手术HP (NS-HP)和健康对照患者的骨强度和微观结构。共入组54例PHP1患者(14例PHP1a, 40例PHP1b), 54例年龄/性别匹配的NS-HP患者和27例年龄/性别匹配的对照组。分别收集临床特征、生化指标及HR-pQCT指标。在诊断和HR-pQCT测量时,PHP1患者的血清Ca和PTH水平均高于NS-HP患者。在HR-pQCT测量时,PHP1患者BMI高于NS-HP患者,血清P水平低于NS-HP患者。骨微结构分析显示,PHP1患者结核减少。N,增加Tb。Sp,增加tb1 /N。与NS-HP患者相比,胫骨SD。亚组分析显示结核无显著性差异。N和Tb。与NS-HP患者相比,PHP1b患者的Sp。多元线性回归分析显示结核增加。N和减少结核。在PHP1b患者中,胫骨Sp与较长的治疗时间相关。本研究中通过HR-pQCT评估的显微结构进一步支持了PHP1患者骨组织对PTH的敏感性保留,小梁骨更容易受到影响。此外,至少PHP1b患者的骨骼状况可能受益于常规治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bone Microstructure and Bone Strength Among Patients with Pseudohypoparathyroidism.

The present study aimed to assess bone strength and microstructure in patients with pseudohypoparathyroidism (PHP), nonsurgical HP (NS-HP), and healthy controls. A total of 54 PHP1 patients (14 PHP1a, 40 PHP1b), 54 age-/sex- matched NS-HP patients and 27 age-/sex-matched controls were enrolled. Clinical characteristics, biochemical indices and HR-pQCT indices were respectively collected. PHP1 patients had higher serum Ca and PTH level than NS-HP patients at the time of both diagnosis and HR-pQCT measurement. A higher BMI and lower serum P level were observed in PHP1 patients than NS-HP patients at the time of HR-pQCT measurement. Bone microstructure analysis showed PHP1 patients had decreased Tb.N, increased Tb.Sp, and increased Tb.1/N.SD at tibia compared to NS-HP patients. Subgroup analysis showed no significant difference in Tb.N and Tb.Sp in PHP1b patients compared to NS-HP patients. Multiple linear regression analysis showed increased Tb.N and decreased Tb.Sp at tibia were associated with longer treatment duration in PHP1b patients. The microarchitecture evaluated by HR-pQCT in this study further supported that bone tissue had a preserved sensitivity to PTH in PHP1 patients and trabecular bone was more susceptible. Moreover, at least, bone status in PHP1b patients might benefit from regular treatment.

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来源期刊
Calcified Tissue International
Calcified Tissue International 医学-内分泌学与代谢
CiteScore
8.00
自引率
2.40%
发文量
112
审稿时长
4-8 weeks
期刊介绍: Calcified Tissue International and Musculoskeletal Research publishes original research and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms and clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions.
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