Marissa Kielly , Andrew Chacon , Anita Caracciolo , David Bolst , Anatoly Rosenfeld , Marco Carminati , Carlo Fiorini , Daniel R. Franklin , Susanna Guatelli , Mitra Safavi-Naeini
{"title":"10B 中子俘获增强粒子疗法中硼中子俘获识别屏蔽策略的探索性研究。","authors":"Marissa Kielly , Andrew Chacon , Anita Caracciolo , David Bolst , Anatoly Rosenfeld , Marco Carminati , Carlo Fiorini , Daniel R. Franklin , Susanna Guatelli , Mitra Safavi-Naeini","doi":"10.1016/j.ejmp.2024.104866","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose:</h3><div>To evaluate the impact of a range of shielding strategies on the rate of false positive detections by a simulated detector for application in Neutron Capture Enhanced Particle Therapy (NCEPT).</div></div><div><h3>Methods:</h3><div>In this work, we extend a previously published method for neutron capture detection and discrimination. A Geant4 Monte Carlo model was designed, with the simulated irradiation of a poly(methyl methacrylate) phantom and cubic <sup>10</sup>B insert with carbon and helium ion beams and various shielding configurations.</div></div><div><h3>Results:</h3><div>In the free-space configuration, shielding the crystal actually decreases the ratio of true/false positive detections (<span><math><msub><mrow><mi>R</mi></mrow><mrow><mi>T</mi><mi>F</mi></mrow></msub></math></span>) by more than 50% and increases the activation of the detector. In a closed-space configuration with a model of the beamline neutron fluence, <span><math><msub><mrow><mi>R</mi></mrow><mrow><mi>T</mi><mi>F</mi></mrow></msub></math></span> also decreases with shielding, although activation decreases in this case. However, for a detector with boron present in the printed circuit boards (PCBs), shielding with a thin layer of Gd<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span>O<span><math><msub><mrow></mrow><mrow><mn>3</mn></mrow></msub></math></span> improves <span><math><msub><mrow><mi>R</mi></mrow><mrow><mi>T</mi><mi>F</mi></mrow></msub></math></span> by up to 21%.</div></div><div><h3>Conclusions:</h3><div>Shielding of the detector crystal itself is unnecessary as shielding actually degrades discrimination accuracy relative to the unshielded detector. However, if the detector PCBs contain boron, then shielding the electronics provides a valuable increase in overall detector selectivity.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"129 ","pages":"Article 104866"},"PeriodicalIF":3.3000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An exploratory study of shielding strategies for boron neutron capture discrimination in 10B Neutron Capture Enhanced Particle Therapy\",\"authors\":\"Marissa Kielly , Andrew Chacon , Anita Caracciolo , David Bolst , Anatoly Rosenfeld , Marco Carminati , Carlo Fiorini , Daniel R. Franklin , Susanna Guatelli , Mitra Safavi-Naeini\",\"doi\":\"10.1016/j.ejmp.2024.104866\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose:</h3><div>To evaluate the impact of a range of shielding strategies on the rate of false positive detections by a simulated detector for application in Neutron Capture Enhanced Particle Therapy (NCEPT).</div></div><div><h3>Methods:</h3><div>In this work, we extend a previously published method for neutron capture detection and discrimination. A Geant4 Monte Carlo model was designed, with the simulated irradiation of a poly(methyl methacrylate) phantom and cubic <sup>10</sup>B insert with carbon and helium ion beams and various shielding configurations.</div></div><div><h3>Results:</h3><div>In the free-space configuration, shielding the crystal actually decreases the ratio of true/false positive detections (<span><math><msub><mrow><mi>R</mi></mrow><mrow><mi>T</mi><mi>F</mi></mrow></msub></math></span>) by more than 50% and increases the activation of the detector. In a closed-space configuration with a model of the beamline neutron fluence, <span><math><msub><mrow><mi>R</mi></mrow><mrow><mi>T</mi><mi>F</mi></mrow></msub></math></span> also decreases with shielding, although activation decreases in this case. However, for a detector with boron present in the printed circuit boards (PCBs), shielding with a thin layer of Gd<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span>O<span><math><msub><mrow></mrow><mrow><mn>3</mn></mrow></msub></math></span> improves <span><math><msub><mrow><mi>R</mi></mrow><mrow><mi>T</mi><mi>F</mi></mrow></msub></math></span> by up to 21%.</div></div><div><h3>Conclusions:</h3><div>Shielding of the detector crystal itself is unnecessary as shielding actually degrades discrimination accuracy relative to the unshielded detector. However, if the detector PCBs contain boron, then shielding the electronics provides a valuable increase in overall detector selectivity.</div></div>\",\"PeriodicalId\":56092,\"journal\":{\"name\":\"Physica Medica-European Journal of Medical Physics\",\"volume\":\"129 \",\"pages\":\"Article 104866\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physica Medica-European Journal of Medical Physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1120179724013346\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physica Medica-European Journal of Medical Physics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1120179724013346","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
An exploratory study of shielding strategies for boron neutron capture discrimination in 10B Neutron Capture Enhanced Particle Therapy
Purpose:
To evaluate the impact of a range of shielding strategies on the rate of false positive detections by a simulated detector for application in Neutron Capture Enhanced Particle Therapy (NCEPT).
Methods:
In this work, we extend a previously published method for neutron capture detection and discrimination. A Geant4 Monte Carlo model was designed, with the simulated irradiation of a poly(methyl methacrylate) phantom and cubic 10B insert with carbon and helium ion beams and various shielding configurations.
Results:
In the free-space configuration, shielding the crystal actually decreases the ratio of true/false positive detections () by more than 50% and increases the activation of the detector. In a closed-space configuration with a model of the beamline neutron fluence, also decreases with shielding, although activation decreases in this case. However, for a detector with boron present in the printed circuit boards (PCBs), shielding with a thin layer of GdO improves by up to 21%.
Conclusions:
Shielding of the detector crystal itself is unnecessary as shielding actually degrades discrimination accuracy relative to the unshielded detector. However, if the detector PCBs contain boron, then shielding the electronics provides a valuable increase in overall detector selectivity.
期刊介绍:
Physica Medica, European Journal of Medical Physics, publishing with Elsevier from 2007, provides an international forum for research and reviews on the following main topics:
Medical Imaging
Radiation Therapy
Radiation Protection
Measuring Systems and Signal Processing
Education and training in Medical Physics
Professional issues in Medical Physics.