线粒体 DNA 单核苷酸多态性在神经退行性疾病中的作用机制与临床应用前景

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Neurochemical Research Pub Date : 2024-12-14 DOI:10.1007/s11064-024-04311-9

Mengying Xu, Tianjiao Li, Xuan Liu, Binish Islam, Yuyue Xiang, Xiyan Zou, Jianwu Wang

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引用次数: 0

摘要

线粒体功能障碍被公认为是阿尔茨海默病、帕金森病和亨廷顿病等神经退行性疾病复杂发病机制的关键组成部分。本综述探讨了线粒体 DNA 单核苷酸多态性对线粒体功能的影响，以及它们在这些神经退行性疾病的发病和进展中的作用。此外，还讨论了这些疾病中线粒体调节的现代方法。我们的目标是发现神经退行性疾病的早期诊断目标并制定精准医疗策略，从而为预防和治疗这些疾病提供新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mechanism and Clinical Application Prospects of Mitochondrial DNA Single Nucleotide Polymorphism in Neurodegenerative Diseases

Mitochondrial dysfunction is well recognized as a critical component of the complicated pathogenesis of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. This review investigates the influence of mitochondrial DNA single nucleotide polymorphisms on mitochondrial function, as well as their role in the onset and progression of these neurodegenerative diseases. Furthermore, the contemporary approaches to mitochondrial regulation in these disorders are discussed. Our objective is to uncover early diagnostic targets and formulate precision medicine strategies for neurodegenerative diseases, thereby offering new paths for preventing and treating these conditions.

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来源期刊

Neurochemical Research 医学-神经科学

CiteScore

7.70

自引率

2.30%

发文量

320

审稿时长

6 months

期刊介绍： Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.