原发性震颤的步态速度改变:一项荟萃分析。

IF 2.7 3区 医学 Q3 NEUROSCIENCES
Kenneth Harrison, Brandon M Peoples, Keven G Santamaria Guzman, Emily J Hunter, Harrison C Walker, Jaimie A Roper
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引用次数: 0

摘要

特发性震颤(ET)是一种常见的运动障碍,它会损害步态功能,包括步态速度——这是行动障碍和不良后果的关键标志。这项荟萃分析旨在量化被诊断为ET的个体与未被诊断为运动障碍的人之间的步态速度差异。电子数据库检索了比较ET患者和对照组的步态速度的研究。效应大小使用标准化平均差异(Hedges' g)计算,并使用随机效应模型进行汇总。纳入8项研究(390例ET, 227例对照)。ET患者的步态速度明显慢于对照组。效应大小(Hedges' g = -1.06, 95% CI = -1.47至-0.65,p = 76.9%)。这些发现表明,步态速度缺陷是ET的重要特征,可能反映了小脑功能障碍。这强调了在ET管理中进行步态评估和有针对性的干预以减少跌倒风险和提高生活质量的必要性。了解调节因素,如药物类型和状态、障碍严重程度和年龄,可以为ET的治疗和管理提供显著的好处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gait Velocity Alterations in Essential Tremor: a Meta-Analysis.

Essential tremor (ET) is a prevalent movement disorder that impairs gait function, including gait speed - a critical marker of mobility disability and adverse outcomes. This meta-analysis aimed to quantify differences in gait speed between individuals diagnosed with ET compared to people without a movement disorder diagnosis. Electronic databases were searched for studies comparing gait speed in ET patients and controls. Effect sizes were calculated using standardized mean differences (Hedges' g) and pooled using a random-effects model. Eight studies (390 ET, 227 controls) were included. ET patients exhibited significantly slower gait speeds than controls. The effect size (Hedges' g = -1.06, 95% CI -1.47 to -0.65, p < .001) indicates a large, clinically significant difference. Substantial study heterogeneity was observed (I2 = 76.9%). These findings suggest that gait speed deficits are a significant feature of ET, potentially reflecting cerebellar dysfunction. This highlights the need for gait assessment and targeted interventions in ET management to reduce fall risk and improve quality of life. Understanding the moderating factors such as medication type and state, disorder severity, and age could provide significant benefits in the treatment and management of ET.

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来源期刊
Cerebellum
Cerebellum 医学-神经科学
CiteScore
6.40
自引率
14.30%
发文量
150
审稿时长
4-8 weeks
期刊介绍: Official publication of the Society for Research on the Cerebellum devoted to genetics of cerebellar ataxias, role of cerebellum in motor control and cognitive function, and amid an ageing population, diseases associated with cerebellar dysfunction. The Cerebellum is a central source for the latest developments in fundamental neurosciences including molecular and cellular biology; behavioural neurosciences and neurochemistry; genetics; fundamental and clinical neurophysiology; neurology and neuropathology; cognition and neuroimaging. The Cerebellum benefits neuroscientists in molecular and cellular biology; neurophysiologists; researchers in neurotransmission; neurologists; radiologists; paediatricians; neuropsychologists; students of neurology and psychiatry and others.
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