摘要
背景：黑人成年人患心力衰竭（HF）的风险高于其他人，这可能与心血管风险因素较高以及炎症性饮食模式有关。西方饮食与炎症有关，也是导致心力衰竭的原因之一。三甲胺 N-氧化物是一种与饮食有关的代谢物，会导致炎症，并与肿瘤坏死因子-α（TNF-α）水平升高有关，尤其是在高血脂人群中。膳食炎症指数评分可衡量膳食的炎症潜力和食物的炎症效应：本试验性研究的目的是探讨高血脂黑人患者的西方饮食、饮食炎症指数、三甲胺 N-氧化物、相关协变量和变量与 TNF-α 之间的关系：31名患有心房颤动的黑人参与者（平均年龄为55岁，68%为女性）被纳入研究。采用免疫测定法分析三甲胺 N-氧化物和 TNF-α 的水平。他们填写了一份食物频率问卷，并计算了膳食炎症指数得分和食物组别。分析包括相关性和I检验统计：膳食炎症指数的平均值为-0.38，这表明男性饮食具有抗炎性，而女性饮食的炎症指数则略高。膳食炎症指数得分与膳食胆碱呈负相关，但与三甲胺 N-氧化物或 TNF-α 无关。三甲胺 N-氧化物与年龄呈正相关，与 TNF-α 的相关性也呈中度效应。在膳食炎症指数、TNF-α和三甲胺N-氧化物变量之间没有发现任何关系：讨论：有必要进一步了解炎症性食物的摄入量及其与免疫因素的关系，以便为制定干预措施提供依据。对于患有高血压的黑人成年人来说，考虑炎症性食物的摄入量非常重要，因为年龄的增长可能会影响膳食代谢物的保留。代谢物也可能增加炎症水平。了解这些关系可根据饮食、年龄和文化模式制定有针对性的饮食干预措施。Background: Black adults have a higher risk for heart failure (HF) than others, which may be related to higher cardiovascular risk factors and also inflammatory dietary patterns. The Western diet is associated with inflammation and contributes to HF. Trimethylamine N-oxide is a diet-linked metabolite that contributes to inflammation and is associated with higher tumor necrosis factor-alpha (TNF-α) levels, especially in HF populations. The dietary inflammatory index score measures a diet's inflammatory potential and food's inflammatory effects.
Objective: The purpose of this pilot study was to explore associations between the Western diet, dietary inflammatory index, trimethylamine N-oxide, relevant covariates and variables, and TNF-α in Black persons with HF.
Methods: Thirty-one Black participants (mean age = 55 years, 68% women) with HF were enrolled. Trimethylamine N-oxide and TNF-α levels were analyzed using immunoassays. A food frequency questionnaire was completed, and dietary inflammatory index scores and food groups were calculated. Analyses included correlations and I-test statistics.
Results: Mean dietary inflammatory index score was -0.38, noting an anti-inflammatory diet with slightly higher inflammatory diet scores in men compared to women. The dietary inflammatory index score showed a negative association with dietary choline but not with trimethylamine N-oxide or TNF-α. Trimethylamine N-oxide and age were positively correlated, along with the correlation for TNF-α with a moderate effect size. No relationship was found among dietary inflammatory index, TNF-α, and trimethylamine N-oxide variables.
Discussion: A greater understanding of intake of inflammatory foods and relationships with immune factors is warranted to inform intervention development. In Black adults with HF, it is important to consider the intake of inflammatory foods as increased age may affect the retention of dietary metabolites. Metabolites may also increase the levels of inflammation. Knowledge about these relationships could lead to tailored dietary interventions based on diet, age, and culture patterns.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
