Chi Young Oh, Eugene Kim, Kihun Kim, Hyeoncheol Oh, Jung-Pil Yoon, Tae Sik Goh, Eunjeong Son, Dai Sik Ko, Yun Hak Kim
{"title":"探索手性与乳腺癌的关系：通过系统综述、荟萃分析和孟德尔随机法进行综合分析。","authors":"Chi Young Oh, Eugene Kim, Kihun Kim, Hyeoncheol Oh, Jung-Pil Yoon, Tae Sik Goh, Eunjeong Son, Dai Sik Ko, Yun Hak Kim","doi":"10.1177/17588359241305096","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Given the widespread prevalence of breast cancer as a global malignancy, there is a compelling need to delve into its risk determinants.</p><p><strong>Objective: </strong>This study aims to investigate the potential relationship between indicators of left-handedness and breast cancer, employing systematic review, meta-analysis, and Mendelian randomization methods.</p><p><strong>Design: </strong>Systematic review and meta-analysis.</p><p><strong>Methods: </strong>The systematic review and meta-analysis, encompassing case-control and cohort designs, conducted a database search on June 17, 2022, utilizing Medline and Embase. For Mendelian randomization analysis, the exposure variable, left-handedness, was sourced from the UK Biobank. Data for breast cancer outcomes were obtained from two cohorts: the Breast Cancer Association Consortium and the Finnish Biobank (Finngen).</p><p><strong>Results: </strong>Eight studies were included in the meta-analysis to investigate the correlation between left-handedness and breast cancer in females. The analysis of cohort studies revealed a hazard ratio (HR) of 1.21 (95% confidence interval (CI): 1.01-1.45), whereas case-control studies showed an odds ratio of 0.81 (95% CI: 0.52-1.26). Subgroup analysis indicated an elevated HR in premenopausal left-handed women. However, Mendelian randomization did not confirm a significant association.</p><p><strong>Conclusion: </strong>Our findings suggest a potential correlation between left-handedness and breast cancer, particularly in premenopausal women. However, due to limited studies and unclear supporting theories, definitive conclusions are premature.</p>","PeriodicalId":23053,"journal":{"name":"Therapeutic Advances in Medical Oncology","volume":"16 ","pages":"17588359241305096"},"PeriodicalIF":4.3000,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635856/pdf/","citationCount":"0","resultStr":"{\"title\":\"Exploring the handedness-breast cancer nexus: a comprehensive analysis via systematic review, meta-analysis, and Mendelian randomization.\",\"authors\":\"Chi Young Oh, Eugene Kim, Kihun Kim, Hyeoncheol Oh, Jung-Pil Yoon, Tae Sik Goh, Eunjeong Son, Dai Sik Ko, Yun Hak Kim\",\"doi\":\"10.1177/17588359241305096\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Given the widespread prevalence of breast cancer as a global malignancy, there is a compelling need to delve into its risk determinants.</p><p><strong>Objective: </strong>This study aims to investigate the potential relationship between indicators of left-handedness and breast cancer, employing systematic review, meta-analysis, and Mendelian randomization methods.</p><p><strong>Design: </strong>Systematic review and meta-analysis.</p><p><strong>Methods: </strong>The systematic review and meta-analysis, encompassing case-control and cohort designs, conducted a database search on June 17, 2022, utilizing Medline and Embase. For Mendelian randomization analysis, the exposure variable, left-handedness, was sourced from the UK Biobank. Data for breast cancer outcomes were obtained from two cohorts: the Breast Cancer Association Consortium and the Finnish Biobank (Finngen).</p><p><strong>Results: </strong>Eight studies were included in the meta-analysis to investigate the correlation between left-handedness and breast cancer in females. The analysis of cohort studies revealed a hazard ratio (HR) of 1.21 (95% confidence interval (CI): 1.01-1.45), whereas case-control studies showed an odds ratio of 0.81 (95% CI: 0.52-1.26). Subgroup analysis indicated an elevated HR in premenopausal left-handed women. However, Mendelian randomization did not confirm a significant association.</p><p><strong>Conclusion: </strong>Our findings suggest a potential correlation between left-handedness and breast cancer, particularly in premenopausal women. 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Exploring the handedness-breast cancer nexus: a comprehensive analysis via systematic review, meta-analysis, and Mendelian randomization.
Background: Given the widespread prevalence of breast cancer as a global malignancy, there is a compelling need to delve into its risk determinants.
Objective: This study aims to investigate the potential relationship between indicators of left-handedness and breast cancer, employing systematic review, meta-analysis, and Mendelian randomization methods.
Design: Systematic review and meta-analysis.
Methods: The systematic review and meta-analysis, encompassing case-control and cohort designs, conducted a database search on June 17, 2022, utilizing Medline and Embase. For Mendelian randomization analysis, the exposure variable, left-handedness, was sourced from the UK Biobank. Data for breast cancer outcomes were obtained from two cohorts: the Breast Cancer Association Consortium and the Finnish Biobank (Finngen).
Results: Eight studies were included in the meta-analysis to investigate the correlation between left-handedness and breast cancer in females. The analysis of cohort studies revealed a hazard ratio (HR) of 1.21 (95% confidence interval (CI): 1.01-1.45), whereas case-control studies showed an odds ratio of 0.81 (95% CI: 0.52-1.26). Subgroup analysis indicated an elevated HR in premenopausal left-handed women. However, Mendelian randomization did not confirm a significant association.
Conclusion: Our findings suggest a potential correlation between left-handedness and breast cancer, particularly in premenopausal women. However, due to limited studies and unclear supporting theories, definitive conclusions are premature.
期刊介绍：
Therapeutic Advances in Medical Oncology is an open access, peer-reviewed journal delivering the highest quality articles, reviews, and scholarly comment on pioneering efforts and innovative studies in the medical treatment of cancer. The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers in medical oncology, providing a forum in print and online for publishing the highest quality articles in this area. This journal is a member of the Committee on Publication Ethics (COPE).
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