Session Introduction: Precision Medicine: Multi-modal and multi-scale methods to promote mechanistic understanding of disease.

Precision medicine focuses on developing treatments and preventative strategies tailored to an individual's genomic profile, lifestyle, and environmental context. The Precision Medicine sessions at the Pacific Symposium on Biocomputing (PSB) have consistently spotlighted progress in this domain. Our 2025 manuscript collection features algorithmic innovations that integrate data across scales and diverse data modalities, presenting novel techniques to derive clinically relevant insights from molecular datasets. These studies highlight recent advances in technology and analytics and their application toward realizing the potential of precision medicine to enhance human health outcomes and extend lifespan.