跨过问题细胞的桥梁：骨髓基质细胞转移线粒体，促进 T 细胞生长

IF 40.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Signal Transduction and Targeted Therapy Pub Date : 2024-12-13 DOI:10.1038/s41392-024-02079-6

Lars Fabian Prinz, Roland Tillmann Ullrich, Markus Martin Chmielewski

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引用次数: 0

摘要

鲍德温及其同事在 2024 年 9 月发表在《细胞》（Cell）杂志上的一篇文章中，介绍了一种基于骨髓基质细胞（BMSC）的线粒体转移平台，用于在体外对抗人类 T 细胞的线粒体功能障碍或稀缺性。1 在针对实体瘤的治疗中，当采用 T 细胞疗法似乎遇到 T 细胞衰竭和功能障碍时，这项全面而方法多样的研究产生了一种前景广阔的技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Bridge over troubled cells: bone marrow stromal cells transfer mitochondria to boost T cells

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Bridge over troubled cells: bone marrow stromal cells transfer mitochondria to boost T cells

In an article published in Cell in September 2024, Baldwin and colleagues present a bone marrow stromal cell (BMSC) based mitochondrial transfer platform to combat mitochondrial dysfunction or scarcity in human T cells ex-vivo.¹ This thorough and methodically diverse investigation results in a promising technology at a time when adoptive T cell therapies seem to run against a wall of T cell exhaustion and dysfunction in treatments targeting solid tumors.²

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来源期刊

Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

44.50

自引率

1.50%

发文量

384

审稿时长

5 weeks

期刊介绍： Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.