细胞的守护者：线粒体作为细胞NAD+水平的变阻器

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2024-12-13 DOI:10.1038/s42255-024-01160-2

Fiona M. Fitzpatrick, Nora Kory

引用次数: 0

摘要

一项新的研究表明，亚细胞NAD+池是相互关联的，线粒体作为缓冲剂维持过度消耗细胞器中NAD+依赖的过程，突出了线粒体在NAD+稳态中的关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Guardians of the cell: mitochondria as a rheostat for cellular NAD+ levels

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Guardians of the cell: mitochondria as a rheostat for cellular NAD+ levels

A new study reveals that subcellular NAD+ pools are interconnected, with mitochondria acting as a buffer to maintain NAD+-dependent processes in overconsuming organelles, highlighting the critical role of mitochondria in NAD+ homeostasis.

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.