了解和管理常见瘙痒性皮肤状况的新时代:如何定义、诊断和治疗?

IF 2.9 3区 医学 Q2 DERMATOLOGY
Takahiro Satoh
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引用次数: 0

摘要

炎症性皮肤病的治疗正在进入一个新时代。生物制剂和小分子药物的出现促进了一些以前难以治疗的皮肤疾病的治疗。然而,仍然有一些瘙痒性皮肤状况,许多皮肤科医生发现难以管理。了解这些疾病的确切临床特征和实际病理机制对于开发和适当使用新疗法至关重要。本期《皮肤病学杂志》特别关注三种常见的瘙痒性皮肤病。湿疹是皮肤科最常见的瘙痒性疾病。然而,有多少皮肤科医生完全了解湿疹的确切性质及其特征?在本期特刊中,Tokura等人讨论了湿疹的本质。他们解释了湿疹的词源和经典概念,包括“湿疹三角”。他们还讨论了湿疹的病理机制,基于目前的理解皮肤免疫学。虽然我们最近获得了治疗慢性炎症性皮肤病的强大治疗工具,如特应性皮炎和牛皮癣,但老年人的红皮病仍然难以治疗。一般来说,红皮病的诊断相对简单。然而,尽管经过仔细的检查,往往很难确定疾病的真正原因。山本阐述了老年人红皮病的概念、临床特点、发病机制,以及老年人红皮病与老年人特应性皮炎的区别。对瘙痒的研究远远落后于对疼痛的研究,长期以来,抗组胺药一直主导着与皮肤病相关的瘙痒的治疗。然而,最近在瘙痒研究方面的进展为我们提供了丰富的非组胺性瘙痒知识。在这一期中,Hashimoto等人描述了瘙痒病理生理学的最新发现。他们还解释了无皮疹的全身性和局部瘙痒的机制以及我们如何处理这些情况。这期的评论文章无疑将帮助皮肤科医生更好地理解、诊断和管理这些常见的瘙痒性皮肤状况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A new era for understanding and managing common pruritic skin conditions: How to define, diagnose, and treat?

A new era for understanding and managing common pruritic skin conditions: How to define, diagnose, and treat?

The treatment of inflammatory skin diseases is entering a new era. The advent of biologics and small-molecule agents has facilitated the therapy of some of the previously difficult-to-treat skin conditions. However, there are still several pruritic skin conditions that many dermatologists find difficult to manage. Understanding the precise clinical features and actual pathological mechanisms of these diseases is essential for the development and appropriate use of new therapies. This special issue of the Journal of Dermatology focuses on three common pruritic skin diseases.

Eczema is the most common and well-known pruritic disease in dermatology. However, how many dermatologists fully understand the exact nature of eczema and its characteristics? In this special issue, Tokura et al. discuss the nature of eczema. They explain the etymology and classic concept of eczema, including the ‘eczema triangle’. They also discuss the pathological mechanisms of eczema based on the current understanding of cutaneous immunology.

While we have recently gained powerful therapeutic tools for treating chronic inflammatory skin conditions, such as atopic dermatitis and psoriasis, erythroderma in the elderly remains difficult to treat. In general, the diagnosis of erythroderma is relatively straightforward. Nevertheless, despite careful examinations, it is often difficult to determine the actual cause of the disease. Yamamoto explains the concept, clinical characteristics, and pathogenesis of erythroderma in the elderly, and the difference between elderly erythroderma and elderly atopic dermatitis.

Research into itching has lagged far behind that into pain, and, for a long time, antihistamines have dominated the treatment of itching associated with skin diseases. However, recent advances in the study of itch have provided us with a wealth of knowledge about nonhistaminergic itch. In this issue, Hashimoto et al. describe the latest findings on the pathophysiology of itch. They also explain the mechanisms of generalized and localized pruritus without rash and how we can manage these conditions.

The review articles in this issue will undoubtfully help dermatologists to better understand, diagnose, and manage these common pruritic skin conditions.

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来源期刊
Journal of Dermatology
Journal of Dermatology 医学-皮肤病学
CiteScore
4.60
自引率
9.70%
发文量
368
审稿时长
4-8 weeks
期刊介绍: The Journal of Dermatology is the official peer-reviewed publication of the Japanese Dermatological Association and the Asian Dermatological Association. The journal aims to provide a forum for the exchange of information about new and significant research in dermatology and to promote the discipline of dermatology in Japan and throughout the world. Research articles are supplemented by reviews, theoretical articles, special features, commentaries, book reviews and proceedings of workshops and conferences. Preliminary or short reports and letters to the editor of two printed pages or less will be published as soon as possible. Papers in all fields of dermatology will be considered.
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