谷氨酸脱羧酶65抗体相关癫痫和复视2例报告并文献复习。

IF 2.7 3区 医学 Q3 NEUROSCIENCES
Bofei Chen, Yi Shi, Jiahui Guo, Zhiruo Qiu, Beibei Shen, Lina Jiang, Jiajia Fang
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引用次数: 0

摘要

谷氨酸脱羧酶65 (GAD65)抗体相关的癫痫和复视相对罕见。本文回顾性分析2例gad65相关性癫痫伴复视的发病、诊断和治疗过程。两例患者最初均表现为癫痫发作,随后出现复视和眼球震颤。由于诊断过程不同,两例患者治疗后预后不同。当癫痫患者出现复视和眼球震颤时,这些症状通常很容易归因于抗癫痫药物的副作用或与癫痫无关,这可能导致GAD65神经综合征的可能性被忽视。因此,临床医生应注意抗gad65抗体与复视癫痫患者的潜在关联,避免漏诊。此外,复视和眼球震颤可能是共济失调的先兆,因此,当复视发生时,应开始积极治疗,防止疾病进展,避免患者预后不良。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Glutamic Acid Decarboxylase 65 Antibody-associated Epilepsy and Diplopia: Two Case Reports with Literature Review.

Glutamic acid decarboxylase 65 (GAD65) antibody-associated epilepsy and diplopia are relatively rare. This article retrospectively analyzed the disease development, diagnosis and treatment process of two cases of GAD65-associated epilepsy with diplopia. Both patients initially exhibited seizures, followed by the onset of diplopia and nystagmus. Due to differences in their diagnostic processes, the two patients showed varying prognoses after treatment. When diplopia and nystagmus are present in patients with epilepsy, these symptoms are often easily attributed to the side effects of antiepileptic medications or not associated with the epilepsy, potentially leading to the oversight of the possibility of GAD65 neurological syndrome. Therefore, clinicians should be aware of the potential association of anti-GAD65 antibodies in epilepsy patients presenting with diplopia, avoidance of missed diagnosis. Furthermore, diplopia and nystagmus may be precursors to ataxia, therefore, when diplopia occurs, proactive treatment should be initiated to prevent disease progression and avoid poor patient outcomes.

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来源期刊
Cerebellum
Cerebellum 医学-神经科学
CiteScore
6.40
自引率
14.30%
发文量
150
审稿时长
4-8 weeks
期刊介绍: Official publication of the Society for Research on the Cerebellum devoted to genetics of cerebellar ataxias, role of cerebellum in motor control and cognitive function, and amid an ageing population, diseases associated with cerebellar dysfunction. The Cerebellum is a central source for the latest developments in fundamental neurosciences including molecular and cellular biology; behavioural neurosciences and neurochemistry; genetics; fundamental and clinical neurophysiology; neurology and neuropathology; cognition and neuroimaging. The Cerebellum benefits neuroscientists in molecular and cellular biology; neurophysiologists; researchers in neurotransmission; neurologists; radiologists; paediatricians; neuropsychologists; students of neurology and psychiatry and others.
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