在一组接受检查点抑制剂治疗的黑色素瘤患者中，肝转移与较短的进展后生存率相关。

IF 3.2 Q2 ONCOLOGY

Oncology and Therapy Pub Date : 2024-12-11 DOI:10.1007/s40487-024-00320-4

Miriam Mengoni, Thomas Tüting, Evelyn Gaffal, Andreas D Braun

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引用次数: 0

摘要

免疫疗法（IT）的引入已经改变了转移性黑色素瘤患者的临床护理。然而，仍有许多患者因疾病进展而死亡。在这里，我们分析了IT如何在现实环境中提高生存能力。此外，我们研究了IT是否会改变由组织特异性免疫微环境引起的不同器官转移进展的动态和模式。方法：我们回顾性比较了2015年至2018年接受IT治疗的61例转移性黑色素瘤患者（24例女性，37例男性）与2005年至2008年接受化疗的56例转移性黑色素瘤患者（21例女性，35例男性）的治疗缓解率、总生存期以及转移进展的时间和分布。结果：与接受化疗的患者相比，接受IT治疗的转移性黑色素瘤患者的反应率更高，总生存期更长。此外，与化疗相比，IT治疗改变了转移进展的动态，但没有改变转移进展的模式。有趣的是，接受IT治疗的患者在转移到淋巴结、肺和脑后的寿命明显延长，但在转移到肝脏后却没有延长。结论：我们的研究结果证实了IT在现实世界中的有效性。转移动力学的改变支持了一些研究，表明免疫特权在肝组织微环境中的独特作用增加了对免疫治疗的耐药性。

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Liver Metastases are Associated with a Short Post-Progression Survival in a Real-World Group of Patients with Melanoma Treated with Checkpoint Inhibitors.

Introduction: The introduction of immunotherapy (IT) has transformed clinical care of patients with metastatic melanoma. However, many patients still die as a result of progressive disease. Here we analyzed how IT improved survival in a real-world setting. Additionally, we investigated whether IT alters the dynamics and pattern of metastatic progression in different organs resulting from tissue-specific immune microenvironments.

Methods: We retrospectively compared a group of 61 patients with metastatic melanoma (24 female, 37 male) treated with IT between 2015 and 2018 with a historical control group of 56 patients with metastatic melanoma (21 female, 35 male) treated with chemotherapy between 2005 and 2008 regarding treatment response rates and overall survival as well as the timing and distribution of metastatic progression.

Results: Patients with metastatic melanoma treated with IT showed increased response rates and longer overall survival when compared with patients treated with chemotherapy. In addition, treatment with IT altered the dynamics but not the pattern of metastatic progression when compared with treatment with chemotherapy. Interestingly, patients receiving IT lived significantly longer after metastatic progression to lymph nodes, lungs and brain, but not after metastatic progression to the liver.

Conclusion: Our results confirm the efficacy of IT in a real-world setting. The altered dynamics of metastases supports studies suggesting a unique role of immune privilege in the liver tissue microenvironment that increases resistance to immunotherapy.

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来源期刊

Oncology and Therapy ONCOLOGY-

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 weeks

期刊介绍： Now indexed in PubMed Aims and Scope Oncology and Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality pre-clinical, clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all therapeutic areas. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Oncology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. 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