卵圆孔未闭患者甘油三酯-葡萄糖指数与隐源性卒中的关系。

IF 2.3 4区医学 Q2 HEMATOLOGY

Clinical and Applied Thrombosis/Hemostasis Pub Date : 2024-01-01 DOI:10.1177/10760296241301411

Fatma Esin, Hüseyin Sefa Ince, Semih Aktürk, Fahrettin Tugrul Citekci, Aykan Celik, Ugur Kocabas, Tuncay Kiris, Mustafa Karaca

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引用次数: 0

摘要

目的：本研究旨在探讨经食管超声心动图（TEE）诊断为卵圆孔未闭（PFO）患者的甘油三酯-葡萄糖（TyG）指数与隐源性卒中（CS）的关系。方法：2015年1月至2023年12月在某高等教育研究型医院进行回顾性、单中心研究。研究人群包括1017例连续诊断为PFO的窦性心律患者，其中210例为CS。使用甘油三酯和空腹血糖水平计算TyG指数。结果：CS组患者年龄（47.53±12.34岁）高于对照组（44.40±17.82岁，p = 0.005）。CS组男性比例（56.2%）高于对照组（48.3%,p = 0.042）。实验室结果显示TyG指数升高（8.87±0.51 vs 8.63±0.55,p）。结论：TyG指数升高与PFO患者CS相关。TyG指数可作为评估该人群CS风险的有用生物标志物。

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The Relationship Between the Triglyceride-Glucose Index and Cryptogenic Stroke in Patients with Patent Foramen Ovale.

Objective: This study aimed to investigate the association between the triglyceride-glucose (TyG) index and cryptogenic stroke (CS) in patients diagnosed with patent foramen ovale (PFO) using transesophageal echocardiography (TEE).

Methods: A retrospective, single-center study was conducted at a tertiary education and research hospital from January 2015 to December 2023. The study population included 1017 consecutive patients with sinus rhythm diagnosed with PFO, of whom 210 had CS. The TyG Index was calculated using triglyceride and fasting glucose levels.

Results: Patients with CS were older (47.53 ± 12.34 years) compared to control group (44.40 ± 17.82 years, p = .005). The proportion of males was higher in the CS group (56.2%) compared to the control group (48.3%, p = .042). Laboratory findings revealed higher TyG Index (8.87 ± 0.51 vs 8.63 ± 0.55, p < .001) in patients with CS. TyG Index was an independent predictor of CS in patients with PFO (OR: 2.832, 95%CI: 1.979-4.053 p < .001).

Conclusion: Elevated TyG Index levels was associated with CS in patients with PFO. The TyG index may serve as a useful biomarker for assessing CS risk in this population.

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来源期刊

Clinical and Applied Thrombosis/Hemostasis 医学-外周血管病

CiteScore

4.40

自引率

3.40%

发文量

150

审稿时长

2 months

期刊介绍： CATH is a peer-reviewed bi-monthly journal that addresses the practical clinical and laboratory issues involved in managing bleeding and clotting disorders, especially those related to thrombosis, hemostasis, and vascular disorders. CATH covers clinical trials, studies on etiology, pathophysiology, diagnosis and treatment of thrombohemorrhagic disorders.