感知心理和身体健康作为淋巴水肿患者死亡率和生活质量的预测因素：一项跨越近二十年的前瞻性研究

IF 2 3区心理学 Q3 PSYCHOLOGY, CLINICAL

International Journal of Behavioral Medicine Pub Date : 2024-12-10 DOI:10.1007/s12529-024-10340-z

Katharina Loibnegger-Traußnig, Andreas R Schwerdtfeger, Franz Flaggl

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引用次数: 0

摘要

背景：患有慢性淋巴系统疾病如何影响生活质量和死亡率？淋巴水肿是一种慢性疾病，主要影响妇女，研究很少。到目前为止，评估淋巴水肿死亡率和生活质量的生物心理社会预测因素的纵向研究在很大程度上是缺失的。这项研究旨在确定可能的预测因素，并为治疗方案开辟创新途径。方法：对某淋巴水肿门诊参加康复治疗的192例淋巴水肿患者进行纵向评估。样本中86.2%为女性，年龄在18 ~ 83岁之间（M = 53.42, SD = 12.54），平均BMI （kg/m2）为31.64 （SD = 8.26）。从2002-2006年基线评估开始，随访15-19年（N = 91）。我们评估了死亡率和生活质量的各种潜在的生物心理社会预测因素（即抑郁、焦虑、癌症）。在随访中，19.5%的参与者死亡。结果：年龄、性别和癌症显著预测死亡率（R2 = 0.27）和生活质量（R2 = 0.29）。当同时进入时，焦虑和抑郁显著地预测了生活质量和死亡率。然而，进一步的分析表明抑制作用，当单独输入时，仅对抑郁或焦虑的影响没有达到显著水平。结论：年龄、性别和肿瘤是影响淋巴水肿患者死亡率和生活质量的主要预测因素。死亡率和生活质量的心理预测主要是由于抑制效应，因此在分析心理健康指标对临床结果的贡献时需要谨慎。试验注册：本研究已在德国临床试验注册（标识符DRKS00024450）和开放科学框架（https://doi.org/10.17605/OSF.IO/RHXQJ）进行预注册。

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Perceived Psychological and Physical Health as Predictors of Mortality and Quality of Life in Patients with Lymphedema: A Prospective Study Spanning Almost Two Decades.

Background: How does living with a chronic disease of the lymphatic system affect quality of life and mortality? Lymphedema is a chronic disease mostly affecting women and research is sparse. To this date, longitudinal studies evaluating biopsychosocial predictors for mortality and quality of life in lymphedema are largely missing. This study aims to identify possible predictors and could open innovative ways for treatment options.

Method: Two hundred ninety-two patients with lymphedema partaking in a rehabilitation program in a lymphedema clinic were longitudinally assessed. The sample consisted of 86.2% women, aged between 18 and 83 years (M = 53.42, SD = 12.54), with a mean BMI (kg/m²) of 31.64 (SD = 8.26). Beginning with baseline assessment in 2002-2006, follow-up was evaluated 15-19 years later (N = 91). We assessed a variety of potential biopsychosocial predictors of mortality and quality of life (i.e., depression, anxiety, cancer). At follow-up, 19.5% of participants were deceased.

Results: Age, gender, and cancer significantly predicted mortality (R² = .27) and quality of life (R² = .29). Anxiety and depression significantly predicted both quality of life and mortality when entered simultaneously. However, further analyses indicated suppressor effects and when entered separately, effects solely for depression or anxiety did not reach significance level.

Conclusion: Age, gender, and cancer were the main predictors of mortality and quality of life in patients with lymphedema. Psychological predictors of mortality and quality of life were mainly due to suppressor effects, thus calling for caution when analyzing the contribution of mental health indicators for clinical outcomes.

Trial registration: This study was preregistered with the German Clinical Trials Register (Identifier DRKS00024450) and Open Science Framework ( https://doi.org/10.17605/OSF.IO/RHXQJ ).

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来源期刊

International Journal of Behavioral Medicine PSYCHOLOGY, CLINICAL-

CiteScore

5.20

自引率

3.70%

发文量

期刊介绍： The International Journal of Behavioral Medicine (IJBM) is the official scientific journal of the International Society for Behavioral Medicine (ISBM). IJBM seeks to present the best theoretically-driven, evidence-based work in the field of behavioral medicine from around the globe. IJBM embraces multiple theoretical perspectives, research methodologies, groups of interest, and levels of analysis. The journal is interested in research across the broad spectrum of behavioral medicine, including health-behavior relationships, the prevention of illness and the promotion of health, the effects of illness on the self and others, the effectiveness of novel interventions, identification of biobehavioral mechanisms, and the influence of social factors on health. We welcome experimental, non-experimental, quantitative, qualitative, and mixed-methods studies as well as implementation and dissemination research, integrative reviews, and meta-analyses.