{"title":"药物诱导的类淋巴瘤肉芽肿病表现为孤立的眼周皮肤病变。","authors":"Molly Shott, Diane Wang, Brooke Bertus, Peng Cheng Han, Lauren Veltri, Vlad Codrea, John Nguyen","doi":"10.1097/IOP.0000000000002833","DOIUrl":null,"url":null,"abstract":"<p><p>Lymphomatoid granulomatosis, a rare lymphoproliferative disorder, was previously defined by categorical pulmonary involvement with possible invasion into the skin, central nervous system, liver, and kidneys. However, recent reports have documented confirmed cases of lymphomatoid granulomatosis without lung involvement. Here, the authors describe a 70-year-old male with rheumatoid arthritis on methotrexate who presented with an ulcerating lesion on the right lower eyelid, initially suspicious for a basal cell carcinoma. Biopsy and immunohistochemical staining revealed grade 3 lymphomatoid granulomatosis. Further workup showed no systemic involvement. The patient's presentation was thought to be secondary to chronic immunosuppression with methotrexate. Upon withdrawal of the medication, the lesion regressed. To the authors' knowledge, this is the first case report of methotrexate-induced lymphomatoid granulomatosis presenting with a singular periocular cutaneous lesion.</p>","PeriodicalId":19588,"journal":{"name":"Ophthalmic Plastic and Reconstructive Surgery","volume":" ","pages":"e66-e68"},"PeriodicalIF":1.2000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Medication-Induced Lymphomatoid Granulomatosis Presenting as a Solitary Periocular Cutaneous Lesion.\",\"authors\":\"Molly Shott, Diane Wang, Brooke Bertus, Peng Cheng Han, Lauren Veltri, Vlad Codrea, John Nguyen\",\"doi\":\"10.1097/IOP.0000000000002833\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Lymphomatoid granulomatosis, a rare lymphoproliferative disorder, was previously defined by categorical pulmonary involvement with possible invasion into the skin, central nervous system, liver, and kidneys. However, recent reports have documented confirmed cases of lymphomatoid granulomatosis without lung involvement. Here, the authors describe a 70-year-old male with rheumatoid arthritis on methotrexate who presented with an ulcerating lesion on the right lower eyelid, initially suspicious for a basal cell carcinoma. Biopsy and immunohistochemical staining revealed grade 3 lymphomatoid granulomatosis. Further workup showed no systemic involvement. The patient's presentation was thought to be secondary to chronic immunosuppression with methotrexate. Upon withdrawal of the medication, the lesion regressed. To the authors' knowledge, this is the first case report of methotrexate-induced lymphomatoid granulomatosis presenting with a singular periocular cutaneous lesion.</p>\",\"PeriodicalId\":19588,\"journal\":{\"name\":\"Ophthalmic Plastic and Reconstructive Surgery\",\"volume\":\" \",\"pages\":\"e66-e68\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ophthalmic Plastic and Reconstructive Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/IOP.0000000000002833\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/9 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmic Plastic and Reconstructive Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/IOP.0000000000002833","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/9 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Medication-Induced Lymphomatoid Granulomatosis Presenting as a Solitary Periocular Cutaneous Lesion.
Lymphomatoid granulomatosis, a rare lymphoproliferative disorder, was previously defined by categorical pulmonary involvement with possible invasion into the skin, central nervous system, liver, and kidneys. However, recent reports have documented confirmed cases of lymphomatoid granulomatosis without lung involvement. Here, the authors describe a 70-year-old male with rheumatoid arthritis on methotrexate who presented with an ulcerating lesion on the right lower eyelid, initially suspicious for a basal cell carcinoma. Biopsy and immunohistochemical staining revealed grade 3 lymphomatoid granulomatosis. Further workup showed no systemic involvement. The patient's presentation was thought to be secondary to chronic immunosuppression with methotrexate. Upon withdrawal of the medication, the lesion regressed. To the authors' knowledge, this is the first case report of methotrexate-induced lymphomatoid granulomatosis presenting with a singular periocular cutaneous lesion.
期刊介绍:
Ophthalmic Plastic and Reconstructive Surgery features original articles and reviews on topics such as ptosis, eyelid reconstruction, orbital diagnosis and surgery, lacrimal problems, and eyelid malposition. Update reports on diagnostic techniques, surgical equipment and instrumentation, and medical therapies are included, as well as detailed analyses of recent research findings and their clinical applications.