药物诱导的类淋巴瘤肉芽肿病表现为孤立的眼周皮肤病变。

IF 1.2 4区 医学 Q3 OPHTHALMOLOGY
Molly Shott, Diane Wang, Brooke Bertus, Peng Cheng Han, Lauren Veltri, Vlad Codrea, John Nguyen
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引用次数: 0

摘要

淋巴瘤样肉芽肿病是一种罕见的淋巴细胞增生性疾病,以前被定义为肺部累及,可能侵犯皮肤、中枢神经系统、肝脏和肾脏。然而,最近的报告已证实的病例淋巴瘤样肉芽肿病没有肺累及。在这里,作者描述了一位70岁的男性类风湿关节炎患者,他服用甲氨蝶呤,右下眼睑出现溃疡性病变,最初怀疑为基底细胞癌。活检和免疫组化染色显示3级淋巴瘤样肉芽肿。进一步检查未发现系统性病变。患者的表现被认为是继发于甲氨蝶呤慢性免疫抑制。停药后,病变消退。据我们所知,这是甲氨蝶呤诱导的淋巴瘤样肉芽肿病的第一例报告,表现为单一的眼周皮肤病变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Medication-Induced Lymphomatoid Granulomatosis Presenting as a Solitary Periocular Cutaneous Lesion.

Lymphomatoid granulomatosis, a rare lymphoproliferative disorder, was previously defined by categorical pulmonary involvement with possible invasion into the skin, central nervous system, liver, and kidneys. However, recent reports have documented confirmed cases of lymphomatoid granulomatosis without lung involvement. Here, the authors describe a 70-year-old male with rheumatoid arthritis on methotrexate who presented with an ulcerating lesion on the right lower eyelid, initially suspicious for a basal cell carcinoma. Biopsy and immunohistochemical staining revealed grade 3 lymphomatoid granulomatosis. Further workup showed no systemic involvement. The patient's presentation was thought to be secondary to chronic immunosuppression with methotrexate. Upon withdrawal of the medication, the lesion regressed. To the authors' knowledge, this is the first case report of methotrexate-induced lymphomatoid granulomatosis presenting with a singular periocular cutaneous lesion.

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来源期刊
CiteScore
2.50
自引率
10.00%
发文量
322
审稿时长
3-8 weeks
期刊介绍: Ophthalmic Plastic and Reconstructive Surgery features original articles and reviews on topics such as ptosis, eyelid reconstruction, orbital diagnosis and surgery, lacrimal problems, and eyelid malposition. Update reports on diagnostic techniques, surgical equipment and instrumentation, and medical therapies are included, as well as detailed analyses of recent research findings and their clinical applications.
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