儿童神经肿瘤学：过去四分之一世纪的亮点。

IF 4.8 2区医学 Q1 Biochemistry, Genetics and Molecular Biology

Neoplasia Pub Date : 2025-01-01 DOI:10.1016/j.neo.2024.101098

Phoebe Power , Joelle P Straehla , Jason Fangusaro , Pratiti Bandopadhayay , Neevika Manoharan

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引用次数: 0

摘要

在过去的25年里，儿童神经肿瘤学领域发生了巨大的变化，对儿童中枢神经系统（CNS）肿瘤的生物学基础的理解和转化治疗学的深刻发展定义了这个时代。尽管在生物学、诊断、治疗和实验领域取得了重大进展，但仍存在相当大的挑战，中枢神经系统肿瘤仍然是儿童癌症相关死亡的主要原因。在这里，我们回顾了过去25年来小儿神经肿瘤学领域的重大进展，并强调了未来进展面临的持续障碍。

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Pediatric neuro-oncology: Highlights of the last quarter-century

The last quarter century has heralded dramatic changes in the field of pediatric neuro-oncology, with the era defined by profound developments in the understanding of the biological underpinnings of childhood central nervous system (CNS) tumors and translational therapeutics. Although there have been momentous strides forward in biologic, diagnostic, therapeutic, and experimental domains, considerable challenges remain and CNS tumors remain the leading cause of pediatric cancer-related mortality. Here, we review the significant advances in the field of pediatric neuro-oncology over the last 25 years and highlight ongoing hurdles facing future progress.

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来源期刊

Neoplasia 医学-肿瘤学

CiteScore

9.20

自引率

2.10%

发文量

审稿时长

26 days

期刊介绍： Neoplasia publishes the results of novel investigations in all areas of oncology research. The title Neoplasia was chosen to convey the journal’s breadth, which encompasses the traditional disciplines of cancer research as well as emerging fields and interdisciplinary investigations. Neoplasia is interested in studies describing new molecular and genetic findings relating to the neoplastic phenotype and in laboratory and clinical studies demonstrating creative applications of advances in the basic sciences to risk assessment, prognostic indications, detection, diagnosis, and treatment. In addition to regular Research Reports, Neoplasia also publishes Reviews and Meeting Reports. Neoplasia is committed to ensuring a thorough, fair, and rapid review and publication schedule to further its mission of serving both the scientific and clinical communities by disseminating important data and ideas in cancer research.