开发基础广泛的呼吸道病毒粘膜疫苗面临的挑战

IF 33.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Junghwa Seo, Jordan Polster, Benjamin Israelow, Kizzmekia S. Corbett-Helaire, David R. Martinez
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引用次数: 0

摘要

在上呼吸道感染和复制到高水平的呼吸道病毒具有高度的人际传播性。此外,在野生动物种群中传播的大量突发病毒家族可以在人类气道细胞中复制,因此具有很高的大流行潜在风险。尽管这些呼吸道病毒具有巨大的大流行潜力,但大多数对抗呼吸道病毒的疫苗都是肌肉注射。肌肉注射疫苗可以预防严重的下呼吸道疾病,但不一定能预防上呼吸道病毒的复制和传播。呼吸道粘膜疫苗的一个主要目标是在感染上呼吸道的呼吸道病毒进入的部位引起局部、快速和有效的免疫反应。呼吸道粘膜疫苗应能产生分泌抗体的浆细胞(产生分泌性IgA抗体)和组织驻留记忆B细胞和T细胞,以对抗在上呼吸道复制的病毒。因此,这些疫苗可大大减少地方性和新出现的呼吸道病毒的传播3,4。鉴于目前只有一种经许可的呼吸道粘膜递送的甲型和乙型流感疫苗fluumist5,还有很大的改进空间。fluumist是一种针对甲型和乙型流感的减毒活疫苗,必须在呼吸道黏膜中复制才能产生有效的免疫反应;鉴于这一要求,预先存在的免疫被认为会抑制FluMist的复制,从而降低疫苗的效力。fluumist最近被批准通过自我给药的方式在家庭使用。尽管取得了这一重大里程碑,但疫苗和流行毒株之间存在抗原和遗传错配问题,对疫苗效力产生负面影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Challenges for developing broad-based mucosal vaccines for respiratory viruses

Challenges for developing broad-based mucosal vaccines for respiratory viruses

Challenges for developing broad-based mucosal vaccines for respiratory viruses
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来源期刊
Nature biotechnology
Nature biotechnology 工程技术-生物工程与应用微生物
CiteScore
63.00
自引率
1.70%
发文量
382
审稿时长
3 months
期刊介绍: Nature Biotechnology is a monthly journal that focuses on the science and business of biotechnology. It covers a wide range of topics including technology/methodology advancements in the biological, biomedical, agricultural, and environmental sciences. The journal also explores the commercial, political, ethical, legal, and societal aspects of this research. The journal serves researchers by providing peer-reviewed research papers in the field of biotechnology. It also serves the business community by delivering news about research developments. This approach ensures that both the scientific and business communities are well-informed and able to stay up-to-date on the latest advancements and opportunities in the field. Some key areas of interest in which the journal actively seeks research papers include molecular engineering of nucleic acids and proteins, molecular therapy, large-scale biology, computational biology, regenerative medicine, imaging technology, analytical biotechnology, applied immunology, food and agricultural biotechnology, and environmental biotechnology. In summary, Nature Biotechnology is a comprehensive journal that covers both the scientific and business aspects of biotechnology. It strives to provide researchers with valuable research papers and news while also delivering important scientific advancements to the business community.
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