与人工授精和胚胎移植服务的荷斯坦小母牛繁殖时间相关的基因组区域。

IF 3.4 2区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Genomics Pub Date : 2025-01-01 Epub Date: 2024-12-02 DOI:10.1016/j.ygeno.2024.110972

Victoria Kelson, Jennifer Kiser, Kimberly Davenport, Emaly Suarez, Brenda Murdoch, Holly Neibergs

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引用次数: 0

摘要

本研究旨在确定人工授精（AI, n = 2754）或胚胎移植（ET, n = 1566）受体荷斯坦小母牛成功妊娠次数（TBRD）相关的基因座（p -5）和基因集（归一化富集评分（NES） ≥ 3.0）。8个基因座与人工授精母牛的TBRD相关（p -5），4个基因座与ET受体的TBRD相关。利用SNP数据对基因集进行富集分析，发现人工智能犊牛中有1个基因集富集TBRD (NES ≥ 3.0)，ET受体中有2个基因集富集TBRD。人工授精和体外授精的拟遗传率分别为0.063和0.043。鉴定与胚胎丢失相关的基因位点有助于选择人工授精或体外授精的繁殖效率更高的荷斯坦小母牛。

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Genomic regions associated with Holstein heifer times bred to artificial insemination and embryo transfer services.

This study aimed to identify loci (p < 1 × 10^-5) and gene sets (normalized enrichment score (NES) ≥ 3.0) associated with the number of times a heifer is bred to attain a successful pregnancy (TBRD) for Holstein heifers bred by artificial insemination (AI, n = 2754) or that were embryo transfer (ET, n = 1566) recipients. Eight loci were associated (p < 1 × 10^-5) with TBRD in AI bred heifers and four loci were associated with TBRD in ET recipients. The gene set enrichment analysis with SNP data identified one gene set enriched (NES ≥ 3.0) with TBRD in AI bred heifers and two gene sets that were enriched with TBRD in ET recipients. The estimated pseudo-heritability for times bred to AI was 0.063 and 0.043 for ET. The identification of loci associated with embryonic loss aids in the selection of Holstein heifers with higher reproductive efficiencies that are AI bred or that are ET recipients.

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来源期刊

Genomics 生物-生物工程与应用微生物

CiteScore

9.60

自引率

2.30%

发文量

260

审稿时长

60 days

期刊介绍： Genomics is a forum for describing the development of genome-scale technologies and their application to all areas of biological investigation. As a journal that has evolved with the field that carries its name, Genomics focuses on the development and application of cutting-edge methods, addressing fundamental questions with potential interest to a wide audience. Our aim is to publish the highest quality research and to provide authors with rapid, fair and accurate review and publication of manuscripts falling within our scope.