神经母细胞瘤的自然杀伤细胞疗法。

IF 3.7 4区医学 Q2 CELL BIOLOGY

Cellular immunology Pub Date : 2025-01-01 Epub Date: 2024-11-28 DOI:10.1016/j.cellimm.2024.104898

Abtin Ghasempour, Rashin Mohseni, Pouya Mahdavi Sharif, Amir Ali Hamidieh

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引用次数: 0

摘要

神经母细胞瘤（NB）是儿童最常见的颅外实体瘤，约占所有儿童肿瘤的15%。尽管NB的治疗取得了进展，但高危患者仍然面临着严重的预后。基于NK细胞的过继细胞疗法正成为此类病例的辅助治疗方法。此外，也有证据表明，基于nkt的治疗方法在NB的治疗中具有良好的效果。与过继性T细胞治疗相比，并发症更低，细胞来源更多样，肿瘤识别机制也更复杂，这是NK和基于nkt的治疗的一些优势。这篇综述致力于寻找这一领域的最新进展。

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Natural killer cell-based therapies in neuroblastoma.

Neuroblastoma (NB) is the most common extracranial solid tumor of childhood forming around 15 % of all pediatric tumors. Despite advances in the treatment of NB, high-risk patients still face a grave prognosis. Adoptive cell therapies based on NK cells are becoming an assistive treatment for such cases. Moreover, there is also evidence that NKT-based therapies have promising results in the management of NB. Lower complications in comparison with adoptive T cell therapies, various cell sources, and miscellaneous tumor recognition mechanisms are some of the advantages of NK- and NKT-based therapies. This review is dedicated to searching for recent advances in this field.

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来源期刊

Cellular immunology 生物-免疫学

CiteScore

8.20

自引率

2.30%

发文量

102

审稿时长

30 days

期刊介绍： Cellular Immunology publishes original investigations concerned with the immunological activities of cells in experimental or clinical situations. The scope of the journal encompasses the broad area of in vitro and in vivo studies of cellular immune responses. Purely clinical descriptive studies are not considered. Research Areas include: • Antigen receptor sites • Autoimmunity • Delayed-type hypersensitivity or cellular immunity • Immunologic deficiency states and their reconstitution • Immunologic surveillance and tumor immunity • Immunomodulation • Immunotherapy • Lymphokines and cytokines • Nonantibody immunity • Parasite immunology • Resistance to intracellular microbial and viral infection • Thymus and lymphocyte immunobiology • Transplantation immunology • Tumor immunity.