鼠尾草酸通过调节小鼠睾丸热休克蛋白和凋亡蛋白来预防热应激诱导的氧化损伤。

IF 2.9 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biological Chemistry Pub Date : 2024-12-06 Print Date: 2024-12-17 DOI:10.1515/hsz-2023-0374

Sirui Liu, Jiaxin Wu, Wanqing Liang, Yinkun Liu, Shuangshuang Wan, Shu Tang

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引用次数: 0

摘要

热应激对畜牧业雄性生殖的影响。鼠尾草酸（CA）是一种有效的抗氧化剂，可以减轻氧化应激和细胞凋亡。α b -晶体蛋白是一种小热休克蛋白，可调节细胞凋亡和氧化应激。本研究探讨了CA对热应激下野生型和α b -晶蛋白敲除小鼠睾丸的保护作用。CA预处理提高了野生型小鼠的睾丸激素水平，并保留了睾丸结构，但在敲除小鼠中没有变化。CA降低Hsp27、Hsp70和cleaved caspase-3水平，而敲除小鼠显示cleaved caspase-3水平升高。这些结果表明，CA通过调节热休克和细胞凋亡相关蛋白来保护睾丸。

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Carnosic acid prevents heat stress-induced oxidative damage by regulating heat-shock proteins and apoptotic proteins in mouse testis.

Heat stress impacts male reproduction in animal husbandry. Carnosic acid (CA), a potent antioxidant, mitigates oxidative stress and apoptosis. αB-crystallin, a small heat shock protein, regulates apoptosis and oxidative stress. This study examines the protective effects of CA on the testis in wild-type and αB-crystallin knockout mice under heat stress. CA pretreatment increased testosterone levels and preserved testicular structure in wild-type mice, but no changes in knockout mice. CA reduced Hsp27, Hsp70, and cleaved caspase-3 levels, while knockout mice showed increased cleaved caspase-3. These results suggest that CA protects the testis by modulating heat shock and apoptosis-related proteins.

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来源期刊

Biological Chemistry 生物-生化与分子生物学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Biological Chemistry keeps you up-to-date with all new developments in the molecular life sciences. In addition to original research reports, authoritative reviews written by leading researchers in the field keep you informed about the latest advances in the molecular life sciences. Rapid, yet rigorous reviewing ensures fast access to recent research results of exceptional significance in the biological sciences. Papers are published in a "Just Accepted" format within approx.72 hours of acceptance.